Hiroto Kawasaki

A genome-wide catalog of sites where peripheral DNA methylation reflects the brain

The paper identifies brain-peripheral DNA methylation sites (BrESS) that consistently predict brain methylation across tissues, showing they are not linked to disease heritability.

Hippocampal-cingulate dynamics in the human brain link reinforcement-learning and memory

This study links reinforcement learning computations to memory by showing hippocampal-cingulate dynamics in humans during a gambling task.

Network and hierarchical organization of intrinsic timescales in the human brain

This paper measures neural timescales in human iEEG data and links them to cortical hierarchy and network topology, showing that timescales increase with hierarchical position and are modulated by sleep stages.

Early reactivation of medial temporal lobe neurons during emergence from propofol anesthesia in neurosurgical patients

This study records single neuron activity in humans during emergence from propofol anesthesia, showing increased firing rates and shifts in brain activity patterns in medial temporal regions before motor response to verbal command.

Transcranial magnetic stimulation to the dorsolateral prefrontal cortex modulates single-neuron activity in humans

This study shows that TMS to the dlPFC modulates single-neuron activity in humans, with facilitation of inhibitory firing and suppression of excitatory drive in specific brain networks.

Exercise enhances hippocampal-cortical ripple interactions in the human brain

This study shows that a single exercise session increases hippocampal ripples and enhances their coupling with cortical networks in humans.

High-Frequency Spinal Cord Stimulation Reorganizes Cortical Cross-Frequency Coupling in a Region- and Time-Dependent Manner

This study shows high-frequency spinal cord stimulation changes cortical cross-frequency coupling in different brain regions and over time, with distinct effects in association and somatosensory cortices.

Brain-wide single-neuron bases of working memory for sounds in humans

The paper uses human intracranial recordings to study neural activity during an auditory working memory task, finding attractor-like states in brain regions associated with memory maintenance and adjustment.

Reading specific memories from human neurons before and after sleep

This paper develops a transformer model to decode specific memories from human neuronal activity before and after sleep, finding differential contributions from brain regions.

Dexmedetomidine produces more sleep-like brain activity compared to propofol

This study compares brain activity during dexmedetomidine and propofol anesthesia to natural sleep using iEEG, finding dexmedetomidine more similar to sleep in certain metrics.

Glial Contribution to the Pathogenesis of Post-Operative Delirium Revealed by Multi-omic Analysis of Brain Tissue from Neurosurgery Patients

This study uses multi-omic analysis of brain tissue from POD patients to show glial cell contributions to pathogenesis, identifying epigenetic and transcriptomic changes in microglia and astrocytes.

Human insula neurons respond to simple sounds during passive listening

The paper reports single neuron responses in the human insula to simple sounds during passive listening, showing frequency tuning and shorter response durations compared to auditory cortex.

The gene expression signature of electrical stimulation in the human brain

This study identifies the gene expression changes in the human brain following electrical stimulation, revealing non-neuronal cell involvement and a conserved gene signature.

Distribution of multi-unit pitch responses recorded intracranially from human auditory cortex

This study records multi-unit pitch responses from human auditory cortex and finds they are distributed across Heschl's gyrus, not localized to a specific region.

Temporally organized representations of reward and risk in the human brain

This study uses iEEG to show how reward and risk computations are temporally organized in the human brain, revealing cascading and parallel encoding patterns.

Consciousness is indexed by analogous cortical reorganization during sleep and anesthesia

The paper identifies common neural signatures of consciousness loss and recovery during sleep and anesthesia using intracranial EEG and diffusion map embedding.

Epigenetics of post-operative delirium: A genome-wide DNA methylation study of neurosurgery patients

This study identifies DNA methylation changes associated with post-operative delirium in neurosurgery patients using genome-wide analysis of blood samples.

Immediate neural network impact after the loss of a semantic hub

This study examines the neural impact of disconnecting a semantic hub in the human brain and finds specific network changes and partial compensation.

Functional geometry of auditory cortical resting state networks derived from intracranial electrophysiology

The paper maps auditory cortical networks using resting state intracranial electrophysiology, revealing hierarchical organization across spatial scales and frequency-dependent hub identities.

Common Fronto-temporal Effective Connectivity in Humans and Monkeys

The paper identifies common effective connectivity patterns between auditory cortex and fronto-temporal regions in humans and monkeys using functional imaging and electrical stimulation.

Focal cortical surface cooling is a novel and safe method for intraoperative functional brain mapping

This paper evaluates the safety of focal cortical cooling as an alternative to electrical cortical stimulation for intraoperative functional brain mapping, finding no intraoperative seizures and comparable post-operative outcomes.

Oscillatory correlates of auditory working memory examined with human electrocorticography

This study investigates oscillatory activity in human brain regions during auditory working memory using electrocorticography, finding sustained low-frequency increases in medial temporal lobe regions.

Differential causal involvement of human auditory and frontal cortices in vocal motor control

This study investigates the role of frontal and auditory cortices in vocal motor control using direct electrical stimulation in patients, showing distinct contributions of these regions to vocal initiation and feedback-dependent control.

Cortical functional connectivity indexes arousal state during sleep and anesthesia

The paper examines cortical functional connectivity during sleep and anesthesia to identify changes in arousal states and suggests common mechanisms of loss of consciousness.

A sound-sensitive source of alpha oscillations in human non-primary auditory cortex

The paper investigates alpha oscillations in human non-primary auditory cortex using electrode recordings from epilepsy patients, finding that alpha activity is suppressed during speech processing in a specific region.

Processing of Auditory Novelty Across the Cortical Hierarchy: An Intracranial Electrophysiology Study

This study uses intracranial electrophysiology to investigate auditory novelty processing in humans, showing distinct spatiotemporal patterns of cortical activation across time scales.

Intracranial Markers of Conscious Face Perception in Humans

This study identifies brain activity patterns in the fusiform gyrus and superior temporal sulcus that distinguish seen from unseen faces and upright from inverted faces using ECoG data.

Surgically disconnected temporal pole exhibits resting functional connectivity with remote brain regions

The paper examines functional connectivity of surgically disconnected temporal pole using resting-state fMRI and finds significant connectivity with remote regions despite anatomical disconnection.

Contents of Consciousness Investigated as Integrated Information in Direct Human Brain Recordings

The paper tests if integrated information theory applies to conscious experience by analyzing brain recordings and finding that integrated information structures classify visual experiences more accurately than other measures.