Shin‐ichi Muramatsu

How Alzheimer's Abeta propagates and triggers tau pathology in intact neurons

This paper shows how Alzheimer's A{beta} spreads through the neurovascular unit, triggering tau pathology via specific signaling pathways in endothelial and pericyte cells.

Prefrontal coding of learned and inferred knowledge during REM & NREM sleep

The paper shows that NREM and REM sleep play distinct roles in forming inferential knowledge, with NREM organizing learned information and REM computing inferences from it.

Efficient Gene Transduction in Pigs and Macaques with the Engineered AAV Vector AAV.GT5 for Hemophilia B Gene Therapy

This study evaluates the efficacy and immunogenicity of the AAV.GT5 vector for hemophilia B gene therapy in pigs and macaques, finding improved transduction and reduced immunogenicity compared to AAV-Spark100.

The hippocampus as a sorter and reverberatory integrator of sensory inputs

This study shows that reverberatory activity in the hippocampus links conditioned and unconditioned stimuli during memory encoding in mice.

HOTARU: Automatic sorting system for large scale calcium imaging data

The paper introduces an improved CNMF-based algorithm for calcium imaging data analysis, enhancing cell detection accuracy and signal quality.

Deletion of class II ARF causes essential tremors through Nav1.6 traffic impairment

This study shows that deletion of class II ARF causes essential tremors by impairing Nav1.6 trafficking to Purkinje cell axon initial segments.

Glucocorticoid receptor-mediated amygdalar metaplasticity underlies adaptive modulation of fear memory by stress

This study shows that stress-induced glucocorticoid receptor activity in the amygdala modulates fear memory through GR-dependent synaptic plasticity mechanisms.