Christopher Keith Tuggle

A single-cell immune atlas of primary and secondary lymphoid organs in pigs

This study creates a single-cell immune atlas of pig lymphoid organs using scRNA-seq, identifying conserved immune cell populations between pigs and humans.

Construction of a multi-tissue cell atlas reveals cell-type-specific regulation of molecular and complex phenotypes in pigs

This study constructs a multi-tissue cell atlas of pigs, identifies cell-type-specific gene regulation, and links these to complex traits and human phenotypes.

Effect of Genotype and Age on a Defined Microbiota in Gnotobiotic SCID Piglets

The study tests the effect of microbiota complexity and age on gut microbiota stability in SCID piglets, finding age affects composition but not genotype, and the 7-strain consortium is most stable.

Definition of regulatory elements and transcription factors controlling immune cell gene expression at single cell resolution using single nucleus ATAC-seq

This study uses snATAC-seq to define regulatory elements and transcription factors controlling gene expression in porcine PBMCs at single-cell resolution.

A compendium of genetic regulatory effects across pig tissues

The paper presents PigGTEx, a resource linking genetic variants to transcriptomic phenotypes in pigs, showing pigs' similarity to humans in gene regulation and complex traits.

A comparative analysis of chromatin accessibility in cattle, pig, and mouse tissues

The paper identifies and compares chromatin accessibility in cattle, pig, and mouse tissues using ATAC-seq, finding species-specific regulatory elements and conservation patterns.

An improved pig reference genome sequence to enable pig genetics and genomics research

The paper presents improved pig reference genomes using long-read sequencing, enhancing continuity and accuracy for pig genetics and genomics research.