Author

Tim S. Heistek

Amsterdam NeuroscienceORCID 0000-0002-4233-8902Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:cell type annotation· 7 Assay:electronic health records· 6 Organism:human· 6 Organism:mouse· 4 Organism:rat· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2

Frequent Co-Authors

Huibert D. MansvelderiD· 8 shared Anna A. GalakhovaiD· 7 shared Natalia A. GoriounovaiD· 6 shared Christiaan P. J. de KockiD· 5 shared Alice MukoraiD· 4 shared Amanda GaryiD· 4 shared Augustin RuiziD· 4 shared Brian E. KalmbachiD· 4 shared

Activity by Year

2019-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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8 shared papersNeuroscience

Huibert D. MansvelderORCID

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Author profile →

10 papers

Recent·Most cited

Human Neocortical Glutamatergic Neurons Revealed Through Multimodal Profiling

Rachel A. Dalley, Sarah Walling-Bell, Jeremy A. Miller, Femke Waleboer, Julian Thijssen, Audrey McCutcheon, Emily C. Gelfand, Matthew Mallory, Cristina Radaelli, Xiao-Ping Liu, Scott Sawchuk, Lauren Alfiler, Julia Wilson, Jeanelle Ariza, Angela P. Ayala, , Herman Tung

The paper integrates multimodal data to characterize human neocortical glutamatergic neurons, revealing morphoelectric properties that distinguish transcriptomic subclasses and highlight species-specific differences.

bioRxiv · Jan 16, 2026 · PreprintNeuroscience

Lateral hypothalamic GABAergic neurons encode alcohol memories.

Isis Alonso-Lozares, Pelle Wilbers, Lina Asperl, Sem Teijsse, Charlotte van der Neut, Dustin Schetters, Yvar van Mourik, Allison J. McDonald, Tim S. Heistek, Huibert D. Mansvelder, Taco J. De Vries, Nathan J. Marchant

This study investigates how lateral hypothalamic GABAergic neurons encode and express alcohol-related memories through behavioral experiments and optogenetic manipulation.

Current Biology · Feb 28, 2024Peer-reviewedNeuroscience

Morpho-electric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex

Thomas Chartrand, Rachel A. Dalley, Jennie Close, Natalia A. Goriounova, Brian Lee, Rusty Mann, Jeremy A. Miller, Gábor Molnár, Alice Mukora, Lauren Alfiler, Katherine S. Baker, Trygve E. Bakken, Jim Berg, Darren Bertagnolli, Thomas Braun, , Ed S. Lein

The paper identifies transcriptomic and morpho-electric diversity in human neocortical layer 1 interneurons, revealing greater subclass distinction compared to mouse.

Science · Oct 12, 2023Peer-reviewedNeuroscience

Structural and functional specializations of human fast spiking neurons support fast cortical signaling

René Wilbers, Anna A. Galakhova, Stan L.W. Driessens, Tim S. Heistek, Verjinia D. Metodieva, Jim Hagemann, Djai B. Heyer, Eline Jasmijn Mertens, Suixin Deng, Sander Idema, Philip C. De Witt Hamer, David P. Noske, Paul van Schie, Ivar O. Kommers, Guoming Luan, , Natalia A. Goriounova

The paper identifies structural and functional adaptations in human fast spiking neurons that enable fast inhibition despite increased cortical distances.

Science Advances · Oct 12, 2023Peer-reviewedNeuroscience

Signature morpho-electric properties of diverse GABAergic interneurons in the human neocortex

Brian Lee, Rachel A. Dalley, Jeremy A. Miller, Thomas Chartrand, Jennie Close, Rusty Mann, Alice Mukora, Lindsay Ng, Lauren Alfiler, Katherine S. Baker, Darren Bertagnolli, Krissy Brouner, Tamara Casper, Éva Csajbók, Nicholas P. Donadio, , Ed S. Lein

The paper uses viral labeling and Patch-seq to define morpho-electric properties of GABAergic interneurons in human neocortex, revealing functional insights and reclassifying some SST neurons into PVALB subclass.

Science · Oct 12, 2023Peer-reviewedNeuroscience

Morpho-electric and computational properties of three types of human hippocampal CA1 pyramidal neurons

Eline Jasmijn Mertens, Yoni Leibner, Jean L. Pie, Anna A. Galakhova, Femke Waleboer, Julia Meijer, Tim S. Heistek, René Wilbers, Djai B. Heyer, Natalia A. Goriounova, Sander Idema, Matthijs B Verhoog, Brian E. Kalmbach, Brian R. Lee, Ryder P. Gwinn, , Christiaan P. J. de Kock

The paper maps morpho-electric and computational properties of human hippocampal CA1 pyramidal neurons and identifies three distinct cell types with unique biophysical features.

bioRxiv · Oct 5, 2023 · PreprintNeuroscience

Proximity of astrocyte leaflets to the synapse determines memory strength

Aina Badia‐Soteras, Tim S. Heistek, Mandy S. J. Kater, Aline Mak, Adrian Negrean, Michel C. van den Oever, Huibert D. Mansvelder, Baljit S. Khakh, Rogier Min, August Benjamin Smit, Mark H. G. Verheijen

This study shows that astrocyte leaflet structure, regulated by Ezrin, affects memory strength by controlling glutamate diffusion and synaptic function in the hippocampus.

Biological Psychiatry · Oct 29, 2022Peer-reviewedNeuroscience

Role of anterior insula cortex in context-induced relapse of nicotine-seeking

Hussein Ghareh, Isis Alonso-Lozares, Dustin Schetters, Rae J. Herman, Tim S. Heistek, Yvar van Mourik, Philip Jean-Richard-dit-Bressel, Gerald Zernig, Huibert D. Mansvelder, Taco J. De Vries, Nathan J. Marchant

This study identifies the anterior insula cortex's role in context-induced relapse to nicotine-seeking using a rodent model and chemogenetic inhibition.

eLife · May 10, 2022Peer-reviewedNeuroscience

Human cortical expansion involves diversification and specialization of supragranular intratelencephalic-projecting neurons

Jim Berg, Staci A. Sorensen, Jonathan T. Ting, Jeremy A. Miller, Thomas Chartrand, Anatoly Buchin, Trygve E. Bakken, Agata Budzillo, Nick Dee, Song‐Lin Ding, Nathan W. Gouwens, Rebecca D. Hodge, Brian E. Kalmbach, Changkyu Lee, Brian Lee, , Josef Šulc

The paper identifies transcriptomic diversity in human supragranular neurons and links it to functional specialization and disease vulnerability.

bioRxiv · Mar 31, 2020 · PreprintNeuroscience

Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention

Joshua Obermayer, Antonio Luchicchi, Tim S. Heistek, Sybren F. de Kloet, Huub Terra, Bastiaan Bruinsma, Ouissame Mnie‐Filali, Christian Kortleven, Anna A. Galakhova, Ayoub J. Khalil, Tim Kroon, Allert J. Jonker, Roel de Haan, Wilma D. J. van de Berg, Natalia A. Goriounova, , Huibert D. Mansvelder

The paper identifies ChAT-VIP interneurons in the medial prefrontal cortex that use cholinergic transmission to excite neurons and influence attention.

Nature Communications · Nov 21, 2019Peer-reviewedNeuroscience