Jan Philipp Kreysing

How the TREX-2 complex associates with the nuclear pore

The paper reports an extended structure of the human nuclear pore complex, revealing TREX-2 components as integral parts of the nuclear ring.

Molecular architecture of heterochromatin at the nuclear periphery of primary human cells

This study uses in situ structural biology to reveal the molecular organization of chromatin at the nuclear periphery in human cells.

The vault associates with membranes in situ

This study uses cryo-electron tomography to show vault particles associate with ER and nuclear envelope membranes and enclose ribosomes in Dictyostelium discoideum.

cryoTIGER: Deep-Learning Based Tilt Interpolation Generator for Enhanced Reconstruction in Cryo Electron Tomography

cryoTIGER uses deep learning to generate intermediate tilt images in cryo-electron tomography, improving 3D reconstruction and structural recovery.

Passage of the HIV capsid cracks the nuclear pore

This study investigates how HIV-1 capsids pass through nuclear pores, finding that capsids retain their structure and cause NPC scaffold rings to crack.

High-confidence 3D template matching for cryo-electron tomography

This paper introduces a high-confidence 3D template matching method for CryoET, enabling accurate localization of cellular structures with improved statistical confidence.

Nuclear pores safeguard the integrity of the nuclear envelope

This study shows that nuclear pore complexes dilate during cell differentiation and that Nup133 deficiency prevents this dilation, leading to nuclear envelope instability.