Darryl Lyndon Russell

Proprotein convertase activity regulates cumulus-oocyte-complex matrix integrity and cumulus cell migration during ovulation via a GDF9-dependent mechanism

This study identifies PCSK5A and GDF9 as key regulators of cumulus-oocyte-complex matrix integrity and cumulus cell migration during late ovulation, with implications for fertility therapeutics.

A network of steroid receptor transcription factors regulates ovarian chromatin remodelling in the transition to ovulation

The paper identifies how PGR, AR, and GR interact to regulate chromatin remodeling and gene activation during ovulation.

dFLASH; dual FLuorescent transcription factor Activity Sensor for Histone integrated live-cell reporting and high-content screening

The paper introduces dFLASH, a tool for live-cell reporting of transcription factor activity, demonstrating its use in sensing HIF and PGR activities and screening for HIF pathway modulators.

Core and Flanking bHLH-PAS:DNA interactions mediate specificity and drive obesity

The paper identifies core and flanking DNA interactions in bHLH-PAS transcription factors that determine binding specificity and link to obesity.

Progesterone receptor-A isoform interaction with RUNX transcription factors controls chromatin remodelling at promoters during ovulation

The paper identifies a PGR-A isoform-RUNX interaction that drives chromatin remodelling at promoters during ovulation, revealing a mechanism for ovulation-specific gene regulation.