This study examines the role of GDF15 in pregnancy and neonatal outcomes using a knockout mouse model, finding no major effects on body weight or survival.

Endocrinology · Oct 22, 2024Peer-reviewedPhysiology

Reduced beta-hydroxybutyrate disposal after ketogenic diet feeding in mice

Cody M. Cousineau, Detrick Snyder, JeAnna R. Redd, Sophia Turner, Treyton Carr, Dave Bridges

This study examines how ketogenic diet affects ketone body disposal in different mouse strains, finding reduced disposal in most strains and genetic factors influencing variability.

bioRxiv · May 16, 2024 · PreprintPhysiology

Hippocampus Glutathione S Reductase Potentially Confers Genetic Resilience to Cognitive Decline in the AD-BXD Mouse Population

Michael C. Saul, ELIZABETH M. LITKOWSKI, Niran Hadad, Amy R. Dunn, Stephanie M. Boas, Jon A. L. Willcox, Julia E. Robbins, Yiyang Wu, Vivek M. Philip, Gennifer E. Merrihew, Jea Park, Philip L. De Jager, Dave Bridges, Vilas Menon, David Alan Bennett, , Catherine Cook Kaczorowski

The paper identifies a genetic locus and protein associated with resilience to cognitive decline in AD-BXD mice and links it to human AD traits.

bioRxiv · Jan 9, 2024 · PreprintNeuroscience

The Signaling Pathways Project: an integrated ‘omics knowledgebase for mammalian cellular signaling pathways

Scott A. Ochsner, David Abraham, Kirt A. Martin, Wei Ding, Apollo McOwiti, Wasula H. Kankanamge, Zichen Wang, Kaitlyn J. Andreano, Ross A. Hamilton, Yue Chen, Angelica Hamilton, Marin L. Gantner, Michael Dehart, Shijing Qu, Susan Galloway Hilsenbeck, , Neil J. McKenna

Signaling Pathways Project maps over 10,000 transcriptomic and ChIP-Seq experiments to signaling nodes and ranks node targets by meta-analysis (consensomes), validated against literature and bench assays.

Scientific Data · Oct 31, 2019Peer-reviewedCell Biology✦ In-depth digest