Fatty acids in the tumor microenvironment reprogram neutrophils to induce immunosuppression via adenosine
Rashi Singhal, Nina W. Zhang, Zheng Hong Lee, Hannah Noelle Bell, Prarthana Dalal, Sumeet A. Solanki, Wesley Huang, Ryan James Rebernick, Peter Sajjakulnukit, Himani Jasewicz, Roshan Kumar, Nikhil Kumar Kotla, Amanda Huber, Anitha Vijay Mallappa, Subhash B. Arya, , Yatrik Madhukar Shah
This study identifies a fatty acid-driven neutrophil-adenosine axis that promotes immunosuppression in colorectal cancer and shows that targeting adenosine receptors can enhance immunotherapy responses.
bioRxiv · Apr 6, 2026 · PreprintCancer Biology