Ayşegül Sapmaz

This study identifies USP24 as a novel ISG15 cross-reactive deubiquitinase that de-ISGylates MOV10 to negatively regulate IFN-I production.

This study identifies USP32 as a key factor enabling Salmonella to manipulate Rab14 and Rab11 pathways for intracellular survival.

This paper introduces Huib32, a selective USP32 inhibitor, and two activity-based probes that modulate endosomal processes and provide tools for studying USP32 in cancer and neurodegenerative diseases.

The paper develops a high-throughput synthesis-to-screening method to identify selective USP18 inhibitors from a cyanimide library.

The paper develops covalent probes to target Legionella pneumophila effector enzymes, demonstrating their effectiveness in capturing DupA through in vitro testing and structural analysis.