Author

Tomáš Hanke

University of OxfordORCID 0000-0002-6076-9546Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:non-human primate· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Bette KorberiD· 2 shared Alba Ruiz· 1 shared Amanda R Maxwell· 1 shared Andrew S PekosziD· 1 shared Anthony T. PhaniD· 1 shared Barton F. HaynesiD· 1 shared Beatriz MotheiD· 1 shared Benjamin DavisiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersImmunology

Bette KorberORCID

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Author profile →

4 papers

Recent·Most cited

Impact of RNA modification and IL-12 boosts on mRNA-LNP vaccine-elicited CD8+ T cell responses

Sampa Santra, Michelle A. Lifton, Benjamin Mildenberg, Georgeanna Morton, Han Nhat Tran, Laura L. Sutherland, Robert Parks, Whitney Edwards, Bette Korber, Anthony T. Phan, Christopher A. Hunter, Garima Dwivedi, Benjamin Davis, Justin Su, Mohamad‐Gabriel Alameh, , Barton F. Haynes

This study compares CD8+ T cell and antibody responses in non-human primates using different ratios of modified and unmodified mRNA-LNP vaccines with IL-12 boosting.

bioRxiv · Nov 1, 2026 · PreprintImmunology

Gut archaea drive human MAIT cell responses

Natasha Fisher-Pearson, Martin Joseph Lett, Isaac W. D. Maylam, Connor S. J. Philip, Mariolina Salio, Richard J. Suckling, Robert Alan Simmons, Keir Barnbrook, Benjamin Swift, Walter Godfrey Jaoko, Freddie Kibengo, William Kilembe, Eduard Joachim Sanders, Mark Christopher Coles, Claire F. Pearson, , Jethro S. Johnson

The paper shows that gut archaea produce 5-OP-RU, which activates MAIT cells, linking archaea to human immunity.

bioRxiv · Sep 16, 2026 · PreprintImmunology

PD-1 blockade enhances HIV-1 vaccine-induced CD8+ T-cell responses in PWH early ART-treated

Miguel Ángel Marín, Alba Ruiz, Dan Ouchi, Esther Jiménez‐Moyano, Ruth Peña, Oscar Blanch-Lombarte, Dan Gorman, Richard Barnard, Tomáš Hanke, Bonaventura Clotet, Bonnie J. Howell, Christian Brander, Beatriz Mothe, Júlia G. Prado

This study shows PD-1 blockade enhances HIV-1 vaccine-induced CD8+ T-cell responses in early ART-treated PWH, improving proliferation, IFN-gamma production, and activation.

EBioMedicine · Dec 9, 2025Peer-reviewedImmunology

A conserved region T-cell vaccine for Sarbecoviruses

Marta Escarra‐Senmarti, Jacqueline Brockhurst, Amanda R Maxwell, Taylor Godwin, Tianle Zhang, Yuzheng Chen, Peter K. Um, Ludmila Danilova, Wen-Chi Hsu, Cheng Ting Lin, Tomáš Hanke, William R. Bishai, Andrew S Pekosz, Cory F. Brayton, Bette Korber, Maximillian Rosario

This paper presents a T-cell vaccine targeting conserved regions across Sarbecoviruses to provide cross-protection against evolving variants.

bioRxiv · May 20, 2025 · PreprintImmunology