Rutger N.U. Kok

NuclearIDTracker uses nuclear phenotypic signatures to classify intestinal cell types and track lineage dynamics without fluorescent reporters.

This study shows that mechanical strain on intestinal organoids reduces the maturity of absorptive lineage cells by expanding early-stage enterocytes and downregulating maturation programs.

This study shows that localized hydrogen peroxide production induces p53-dependent resistance to DNA damage, with implications for chemotherapy protection.

This study shows WNT7B drives pancreatic cancer subtype switching and progression by promoting a basal-like state and influencing cell communication within tumors.

This paper introduces an algorithm that assigns error probabilities to cell tracks, enabling automated analysis and reducing manual curation needs in cell tracking.

OrganoidTracker automates cell tracking in organoids using machine learning and manual error correction, achieving high accuracy with minimal manual intervention.