Molly A. Ingersoll

This study shows that bacterial growth under confinement leads to increased turgor pressure, which disrupts division and protein synthesis, and activates the Rcs pathway, with implications for infection physiology.

The paper identifies and functionally characterizes regulatory variants in DPP9 associated with severe COVID-19 by analyzing genetic risk factors and their impact on gene expression and immune cell function.

The paper shows primary cilia on kidney tubular cells initiate a fibro-inflammatory program in response to bacterial components, linking pathogen detection to kidney disease progression.

This study identifies the DanRI regulatory system in UPEC that suppresses neutrophil responses by inhibiting reactive oxygen species production and NET formation, enhancing UPEC fitness in UTI.

This paper introduces an ex vivo bladder infection model using discarded mouse tissue to study host-pathogen interactions in UTI, showing comparable bacterial burden to in vivo models.

This study shows that OM-89 combined with antibiotics reduces recurrent UTI in mice, without affecting adaptive immunity.

This study identifies factors influencing DNA methylation variation in human blood, showing that cytomegalovirus infection and aging drive methylation changes, with cellular composition and DNA sequence as key predictors.

The paper identifies novel genetic and non-genetic factors associated with plasma protein levels in healthy donors, highlighting their impact on immune response variability.