Yan Li

This study examines suzetrigine's effects on human dorsal root ganglion neurons, showing it suppresses spontaneous pain-related discharges but requires longer exposure to affect evoked pain.

The paper shows OSM-OSMR signaling via MAPKs drives transcriptomic changes in human DRG linked to neuropathic pain.

The paper shows that MNK inhibitor eFT508 reduces spontaneous activity in human DRG neurons from painful dermatomes.

The paper profiles RNA in human DRGs from neuropathic pain patients, identifying sex-specific gene expression differences and neuro-immune pathways associated with pain.

The paper shows that human dorsal root ganglion neurons express ACE2, suggesting they may be a target for SARS-CoV-2 entry into the nervous system.

LCA identifies subtle cell population diversity in large-scale single-cell RNA-seq data using a dual-space model with spectral clustering and technical variation control.

The paper identifies the RagA-mTORC1 network as a key driver of neuropathic pain through cell-specific translational profiling in nociceptors.