Jürgen Goldschmidt

Role of Bassoon-mediated active zone integrity at different types of brain synapses for brain activity and cortex-dependent memory formation

This study investigates the role of Bassoon in different synapse types by generating conditional knockout mice, finding distinct effects on brain activity and learning.

Vascular and neural transcriptomics reveal stage-dependent pathways to inflammation and cognitive dysfunction in a rat model of hypertension

This study investigates stage-dependent molecular and cellular changes in a rat model of hypertension, revealing vascular and neural pathways linked to inflammation and cognitive dysfunction.

Preventing Jacob-induced transcriptional inactivation of CREB protects synapses from β-amyloid in Alzheimer's Disease

The paper shows that Nitarsone prevents Aβ-induced CREB inactivation and synaptic loss in AD models by blocking Jacob-mediated signalosome assembly.