Chris MacDonald

Ktd1 is a phospho-regulated member of the Dup240 family that mediates defence against killer toxin K28

This study identifies Ktd1 as a phospho-regulated member of the Dup240 family essential for defense against the K28 killer toxin in yeast.

HaloUMI: Physics-informed analysis of inhibition halo assays

HaloUMI provides an automated tool for analyzing microbial inhibition assays, improving accuracy by accounting for irregular zones and varying microbial density.

Transcriptional responses of acute glucose deprivation reveal a role for Snf12 and Spt20 in metabolic adaptation during stress

This study investigates the transcriptional responses of yeast to glucose deprivation, identifying roles for Snf12 and Spt20 in metabolic adaptation and stress signaling.

Dynamic diffusion analysis of the yeast plasma membrane using Airyscan based microscopic techniques

This study compares FCS and FRAP techniques to measure diffusion in yeast plasma membrane proteins, revealing discrepancies in Sso2 diffusion due to subdomain localization.

Ubiquitinome dynamics and regulation by DUB2 during Leishmania differentiation

This study maps the Leishmania ubiquitinome and identifies DUB2 as a key regulator of differentiation by modulating ubiquitination of proteins involved in cell motility and metabolism.

Uptake mechanisms and physiological effects of furanic compounds from the Maillard reaction in budding yeast

This study investigates the uptake mechanisms and physiological effects of furanic compounds in budding yeast, revealing distinct toxicity pathways for different compounds.

Extracellular vesicle bioactivity and potential clinical utility is determined by mesenchymal stromal cell clonal subtype

This study compares EV bioactivity and clinical utility from two clonal MSC subtypes, finding Y201 EVs show enhanced proliferation effects and in vivo efficacy compared to Y202 EVs.

Killer Toxin K28 resistance in yeast relies on COG complex mediated trafficking of the defence factor Ktd1

This study identifies the COG complex as essential for Ktd1 trafficking, which mediates resistance to the A/B toxin K28 in yeast.

High resolution live cell imaging to define ultrastructural and dynamic features of the halotolerant yeast Debaryomyces hansenii

This study uses high-resolution live cell imaging to characterize sub-cellular structures and dynamic processes in the halotolerant yeast Debaryomyces hansenii, providing a template for studying genetically recalcitrant organisms.