This study investigates the role of Pten in radial glial progenitor lineage progression and astrocyte production during cortical development, finding that Pten loss increases astrocyte generation and disrupts growth factor signaling.

bioRxiv · May 5, 2026 · PreprintNeuroscience

Large neutral amino acid levels tune perinatal neuronal excitability and survival

Lisa S. Knaus, Bernadette Basilico, Daniel Malzl, Maria Gerykova Bujalkova, Mateja Smogavec, Lena A. Schwarz, Sarah Gorkiewicz, Nicole Amberg, Florian M. Pauler, Christian Knittl‐Frank, Marianna Tassinari, Nuno Maulide, Thomas Rülicke, Jörg Menche, Simon Hippenmeyer, Gaia Novarino

The paper investigates how changes in large neutral amino acid metabolism during development affect neuronal excitability and survival, finding that Slc7a5 deletion disrupts lipid metabolism and leads to long-term circuit dysfunction.

Cell · Mar 29, 2023Peer-reviewedNeuroscience

Tissue-wide Genetic and Cellular Landscape Shapes the Execution of Sequential PRC2 Functions in Neural Stem Cell Lineage Progression

Nicole Amberg, Florian M. Pauler, Carmen Streicher, Simon Hippenmeyer

The paper shows PRC2 has distinct, sequential functions in RGP lineage progression, acting tissue-wide for proliferation and cell-autonomously for astrocyte maturation.

Science Advances · Nov 2, 2022Peer-reviewedNeuroscience

A Genome-wide Library of MADM Mice for Single-Cell Genetic Mosaic Analysis

Ximena Contreras, Nicole Amberg, Amarbayasgalan Davaatseren, Andi H. Hansen, Johanna Sonntag, Lill Andersen, Tina Bernthaler, Carmen Streicher, Anna Heger, Randy L. Johnson, Lindsay A. Schwarz, Liqun Luo, Thomas Rülicke, Simon Hippenmeyer

The paper introduces a genome-wide MADM mouse library enabling single-cell genetic mosaic analysis and uses it to study chromosome-specific segregation biases in stem cell division.

Cell Reports · Jun 1, 2021Peer-reviewedDevelopmental Biology