Ruihan Zhang

RnR-ExM: Robust Non-rigid Registration Challenge for Expansion Microscopy Volumes

The paper presents a challenge for 3D registration of expansion microscopy volumes, evaluates top methods, and highlights future directions for ExM registration.

Expansion Revealing of Pathology Resolves Nanostructures Associated with Inflammatory Phenotypes in COVID-19 Decedent Human Brain Tissue

The paper introduces ExRPath and 15ExMPath techniques to expand human brain tissue for nanostructure analysis, revealing amyloid nanoclusters associated with SARS-CoV-2 in COVID-19 patients.

Recording of cellular physiological histories along optically readable self-assembling protein chains

The paper introduces a method to record cellular physiological histories using self-assembling protein chains that can be optically read, demonstrating its use in neurons and mouse brain.

Expansion Sequencing of RNA Barcoded Neurons in the Mammalian Brain: Progress and Implications for Molecularly Annotated Connectomics

The paper introduces ExBarSeq, a method for high-resolution multiplexing of barcodes and synaptic proteins in neurons, demonstrating its application in mouse brain tissue.

MicroRNA miR-7 and miR-17-92 in POMC neurons are associated with sex-specific regulation of diet-induced obesity

The paper shows miR-7 and miR-17-92 in POMC neurons regulate sex-specific diet-induced obesity through sex-differential gene expression.