The paper quantifies octadecanoid oxylipins in a cnidarian-dinoflagellate symbiosis and identifies specific lipid mediators associated with symbiont identity and host response.

Communications Biology · Nov 4, 2025Peer-reviewedBiochemistry

OMICmAge: An integrative multi-omics approach to quantify biological age with electronic medical records

Qingwen Chen, Varun Bhamidipati Dwaraka, Natàlia Carreras-Gallo, Kevin M. Mendez, Yulu Chen, Sofina Begum, Priyadarshini Kachroo, Nicole Prince, Hannah Went, Tavis L. Mendez, Aaron Lin, Logan Turner, Mahdi Moqri, Su H. Chu, Rachel S. Kelly, , Jessica Ann Lasky-Su

The paper develops OMICmAge, a multi-omics biomarker of biological age, and shows it outperforms existing markers in predicting chronic diseases and mortality.

bioRxiv · Oct 16, 2023 · PreprintBioinformatics

Endothelial-derived sphingolipids are required for vascular development and systemic lipid homeostasis

Andrew Kuo, Antonio Checa, Colin Niaudet, Bongnam Jung, Zhongjie Fu, Craig Edward Wheelock, Sasha A. Singh, Masanori Aikawa, Lois E. H. Smith, Richard L. Proia, Timothy Hla

This study shows that endothelial-derived sphingolipids are essential for vascular development and systemic lipid homeostasis, with effects on retinal vascularization and liver toxicity.

eLife · Oct 5, 2022Peer-reviewedDevelopmental Biology

Oral pyruvate prevents glaucomatous neurodegeneration

Pete A. Williams, Jeffrey M. Harder, Chelsea Guymer, John P. M. Wood, Evangelia Daskalaki, Glyn Chidlow, Brynn H. Cardozo, Nicole E. Foxworth, Kelly E. Cochran, Tionna B. Ouellette, Craig Edward Wheelock, Robert James Casson, Simon W. M. John

The paper shows oral pyruvate protects against glaucomatous neurodegeneration in mice by improving bioenergetics and inhibiting mTOR.

bioRxiv · May 2, 2020 · PreprintNeuroscience