Anthony J. D. G. Holtmaat

A sensitive orange fluorescent calcium ion indicator for imaging neural activity

The paper introduces OCaMP, an orange fluorescent calcium indicator that improves sensitivity and performance compared to existing green and red indicators for neural imaging.

Neurogliaform cells mediate interhemispheric modulation of sensory-evoked activity in cortical pyramidal neurons

This study shows neurogliaform cells mediate interhemispheric inhibition and modulate sensory perception by affecting pyramidal neuron activity in the mouse barrel cortex.

Repetitive sensory stimulation potentiates and recruits sensory-evoked cortical population activity

The paper shows that repetitive sensory stimulation increases whisker-evoked cortical activity in awake mice and identifies a disinhibitory mechanism underlying this change.

Higher-order thalamocortical projections selectively control excitability via NMDAR and mGluRI-mediated mechanisms.

This study shows that higher-order thalamocortical projections increase excitability in L2/3 pyramidal neurons via NMDAR and mGluRI mechanisms, distinct from other inputs.

A brain atlas of synapse protein lifetime across the mouse lifespan.

The paper quantifies PSD95 protein lifetime in mouse synapses across lifespan and brain regions, revealing distinct patterns linked to development, behavior, and aging.

An increase in dendritic plateau potentials is associated with experience-dependent cortical map reorganization

The paper shows that increased dendritic plateau potentials, driven by the posterior medial thalamic nucleus, contribute to experience-dependent reorganization of whisker maps in the mouse primary somatosensory cortex.

Dynamic perceptual feature selectivity in primary somatosensory cortex upon reversal learning

This study examines how neuron selectivity in mouse primary somatosensory cortex changes during reversal learning, finding that most neurons exhibit dynamic selectivity influenced by behavioral context.

The mesoSPIM initiative: open-source light-sheet mesoscopes for imaging in cleared tissue

The paper introduces mesoSPIM, an open-source light-sheet microscope initiative for imaging large cleared tissue samples with near-isotropic resolution.

Higher-order thalamocortical inputs gate synaptic long-term potentiation via disinhibiton

The paper identifies a circuit mechanism in mouse somatosensory cortex where higher-order thalamic inputs gate LTP via disinhibition of VIP and suppression of SST interneurons.