This study identifies regulatory innovations in ancient gene programs that drive diapause in the African turquoise killifish, linking chromatin changes to lipid metabolism and survival.

Cell · May 28, 2024Peer-reviewedGenomics

Males deploy multifaceted strategies and hijack longevity pathways to induce premature demise of the opposite sex

Lauren N. Booth, Cheng Shi, Cindy Tantilert, Robin W. Yeo, Jason Wayne Miklas, Katja Hebestreit, Cecilia N. Hollenhorst, Travis J. Maures, Matthew T. Buckley, Coleen Tara Murphy, Anne Brunet

The paper investigates how male sexual interactions negatively affect female and hermaphrodite lifespan in C. elegans, uncovering genes involved in male-induced demise and longevity pathways.

Nature Aging · Sep 16, 2022Peer-reviewedGenetics

Cardiac differentiation at single cell resolution reveals a requirement of hypertrophic signaling for HOPX transcription

Clayton E. Friedman, Quan Hoang Nguyen, Samuel W. Lukowski, Han Sheng Chiu, Abbigail Helfer, Jason Wayne Miklas, Shengbao Suo, Jing‐Dong J. Han, Pierre Osteil, Guangdun Peng, Naihe Jing, Gregory J. Baillie, Anne Senabouth, Angelika N. Christ, Timothy J. C. Bruxner, , Nathan J. Palpant

The paper maps cardiac differentiation at single-cell resolution, identifies HOPX dysregulation, and shows hypertrophic signaling is required for HOPX transcription in hPSC-derived cardiomyocytes.

bioRxiv · Jun 20, 2018 · PreprintDevelopmental Biology