Sibylle G. Schwab

Astrocytic glutamate regulation is shaped by adversity and glucocorticoid signalling

The paper identifies molecular and anatomical diversity in human cortical astrocytes and links adversity and glucocorticoid signalling to glutamate-related synaptic dysfunction in psychiatric disorders.

Improving Polygenic Prediction in Ancestrally Diverse Populations

This paper introduces PRS-CSx, a method that improves polygenic prediction across ancestrally diverse populations by integrating GWAS summary statistics and sharing genetic effects.

Rare schizophrenia risk variant burden is conserved in diverse human populations

The paper investigates the conservation of rare schizophrenia risk variants across diverse populations and finds consistent burden in constrained genes.

Severe childhood and adulthood stress associates with neocortical layer-specific reductions of mature spines in psychiatric disorders

The paper examines how severe childhood and adulthood stress affects dendritic spine density in the human orbitofrontal cortex, finding greater reductions in childhood stress.

Comparative genetic architectures of schizophrenia in East Asian and European populations

This study identifies schizophrenia genetic associations in East Asian and European populations, finding similar genetic effects across ancestries but highlighting challenges in polygenic risk prediction across groups.