Nicolas Vabret

Coordinated macrophage and T cell interactions mediate response to checkpoint blockade in colorectal cancer.

This study identifies T cell and macrophage subsets that mediate response to anti-PD-1 therapy in colorectal cancer, showing that combination therapy can eradicate tumors in both MMRd and MMRp settings.

Repeats Mimic Pathogen-Associated Patterns Across a Vast Evolutionary Landscape

The paper quantifies viral mimicry in genomes across species and shows how repetitive elements maintain pathogen-like features under selection.

Targeting neoantigens conserved across organs and species overcomes tumor immune escape

This study identifies conserved neoantigens across species and tissues that elicit strong immune responses and suppress tumor growth through vaccination.

T cell epitope mapping reveals immunodominance of evolutionarily conserved regions within SARS-CoV-2 proteome.

The paper maps T cell epitopes in SARS-CoV-2, showing that immunodominant regions are conserved across variants and important for immune surveillance.