Author

Tsukasa Kadota

Jikei University School of MedicineORCID 0000-0002-9533-7241Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Organism:mouse· 1

Frequent Co-Authors

Aaron Scott MansfieldiD· 1 shared Andrew J. LechneriD· 1 shared Chaoyuan KuangiD· 1 shared Fia Stratton· 1 shared Hiromichi HaraiD· 1 shared Hironori KawamotoiD· 1 shared Jin Young LeeiD· 1 shared Jun ArayaiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Aaron Scott MansfieldORCID

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2 papers

Recent·Most cited

Senescent fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity

Jin Young Lee, Nabora S. Reyes, Sang‐Ho Woo, Nancy C. Allen, Tsukasa Kadota, Andrew J. Lechner, Ritusree Biswas, Sakshi Goel, Fia Stratton, Chaoyuan Kuang, Tatsuya Tsukui, Vincent C. Auyeung, Aaron Scott Mansfield, Lindsay M. LaFave, Tien Peng

This study identifies senescent fibroblasts in lung cancer stroma that alter tumor metabolism and plasticity, and shows that targeting these cells with XL888 reduces tumor burden.

Cell stem cell · Nov 3, 2025Peer-reviewedCancer Biology

Human bronchial epithelial cell-derived extracellular vesicle therapy for pulmonary fibrosis via inhibition of TGF-β-WNT crosstalk

Tsukasa Kadota, Yu Fujita, Jun Araya, Naoaki Watanabe, Shota Fujimoto, Hironori Kawamoto, Shunsuke Minagawa, Hiromichi Hara, Takashi Ohtsuka, Yusuke Yamamoto, Kazuyoshi Kuwano, Takahiro Ochiya

This paper shows that human bronchial epithelial cell-derived extracellular vesicles reduce pulmonary fibrosis by inhibiting TGF-β-WNT crosstalk through miRNA-mediated mechanisms.

Journal of Extracellular Vesicles · Aug 1, 2021Peer-reviewedMolecular Biology