Marian H. Dore

Defective HIRA driven chromatin maintenance underlies age related decline in oocyte quality

This study identifies HIRA SUMOylation as a cause of chromatin instability in aging oocytes, leading to reduced fertility, and shows similar defects in human oocytes.

CRISPRa-mediated disentanglement of the Dux-MERVL axis in the 2C-like state, totipotency and cell death

The paper investigates the role of Dux and MERVL in ZGA, totipotency, and cell toxicity using CRISPRa and a 2C-GFP reporter system, finding that MERVL activation contributes to expanded fate potential but not all totipotency features, while Dux-induced toxicity is independent of MERVL and involves Noxa.

Cell competition acts as a purifying selection to eliminate cells with mitochondrial defects during early mouse development

The paper identifies mitochondrial defects in eliminated cells during early mouse development and shows that cell competition removes cells with mitochondrial DNA mutations and sequence changes.

FACT mediates cohesin function on chromatin

This study shows that FACT is required for cohesin stability on chromatin and the formation of cohesin-dependent TAD-like structures, but not sister chromatid cohesion.