This study identifies somatic copy number variants (sCNVs) in schizophrenia cases, revealing their contribution to risk and specific NRXN1 disruptions.

Cell Genomics · Jul 6, 2023Peer-reviewedGenetic & Genomic Medicine

Identifying Nootropic Drug Targets via Large-Scale Cognitive GWAS and Transcriptomics

Max Lam, Chia‐Yen Chen, Tian Ge, Yan Xia, David W. Hill, Joey W. Trampush, Jin Yu, Emma Knowles, Gail Davies, Eli A. Stahl, Laura M. Huckins, David C M Liewald, Srdjan Djurovic, Ingrid S. Melle, Andrea Christoforou, , Todd Lencz

This paper identifies potential nootropic drug targets by integrating large-scale cognitive GWAS and transcriptomic data to find credible druggable genes.

Neuropsychopharmacology · May 25, 2021Peer-reviewedGenomics

Evidence for reduced long-term potentiation-like visual cortical plasticity in schizophrenia and bipolar disorder

Mathias Valstad, Daniël Roelfs, Nora Berz Slapø, Clara M.F. Timpe, Ahsan Rai, Anna Maria Matziorinis, Dani Beck, Geneviève Richard, Linn Sofie Sæther, Beathe C. Haatveit, Jan Egil Nordvik, Christoffer Hatlestad‐Hall, Gaute T. Einevoll, Tuomo Mäki‐Marttunen, Marit Haram, , Torbjørn Elvsåshagen

The paper assesses LTP-like visual cortical plasticity in schizophrenia and bipolar disorder using VEP modulation, finding impaired N1b modulation in SZ and BDI but not BDII, linked to symptom severity.

Schizophrenia Bulletin · Apr 7, 2021Peer-reviewedNeuroscience

The genetic architecture of human brainstem structures and their involvement in common brain disorders

Torbjørn Elvsåshagen, Shahram Bahrami, Dennis van der Meer, Ingrid Agartz, Dag Alnæs, Deanna M. Barch, Ramona Baur‐Streubel, Alessandro Bertolino, Mona Kristiansen Beyer, Giuseppe Blasi, Stefan Borgwardt, Birgitte Boye, Jan K. Buitelaar, Erlend Bøen, Elisabeth Gulowsen Celius, , Tobias Kaufmann

The paper identifies genetic loci associated with brainstem volumes and finds genetic overlaps with psychiatric and neurological disorders.

Nature Communications · Aug 11, 2020Peer-reviewedNeuroscience

Genetics of brain age suggest an overlap with common brain disorders

Tobias Kaufmann, Dennis van der Meer, Nhat Trung Doan, Emanuel Schwarz, Martina Jonette Lund, Ingrid Agartz, Dag Alnæs, Deanna M. Barch, Ramona Baur‐Streubel, Alessandro Bertolino, Francesco Bettella, Mona Kristiansen Beyer, Erlend Bøen, Stefan Borgwardt, Christine Lycke Brandt, , Neurocognition and Genetics Study for the Pediatric Imaging

The paper estimates brain age gaps using MRI and machine learning in individuals with and without brain disorders, finding heritability and genetic overlap with common disorders.

Nature Neuroscience · Sep 24, 2019Peer-reviewedNeuroscience

Brain scans from 21297 individuals reveal the genetic architecture of hippocampal subfield volumes

Alzheimer’s Disease Neuroimaging Initiative, Dennis van der Meer, for the Pediatric Imaging, Neurocognition and Genetics Study, Jaroslav Rokicki, Tobias Kaufmann, Aldo Córdova‐Palomera, Torgeir Moberget, Dag Alnæs, Francesco Bettella, Oleksandr Frei, Nhat Trung Doan, Ida Elken Sønderby, Olav Bjerkehagen Smeland, Ingrid Agartz, Alessandro Bertolino, , Lars Tjelta Westlye

This study identifies 15 genome-wide significant loci associated with hippocampal subfield volumes in 21,297 individuals, revealing distinct genetic determinants for different subfields.

Molecular Psychiatry · Oct 2, 2018Peer-reviewedGenetics

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

Niamh Mullins, Tim B. Bigdeli, Anders Dupont Børglum, Jonathan R. I. Coleman, Ditte Demontis, Ayman H. Fanous, Divya Mehta, Robert A. Power, Stephan Ripke, Eli A. Stahl, Anna Starnawska, Adebayo Anjorin, Aiden Peter Corvin, Alan R. Sanders, Andreas J. Forstner, , Stéphane Jamain

This paper conducts a GWAS on suicide attempt across psychiatric disorders, identifying genetic loci and showing polygenic risk for major depression predicts suicide attempt in multiple disorders.

bioRxiv · Sep 14, 2018 · PreprintGenetics