Yannan Chen

In vitro reconstitution of hippocampal cell assemblies

This study demonstrates that dissociated hippocampal cells can self-organize into network dynamics similar to in vivo cognitive cell assemblies, showing resilience and response to perturbations.

Multi-immersion Oblique Plane Microscope (miOPM): A reconfigurable platform for high-resolution Light-Sheet Fluorescence Microscopy.

The paper introduces miOPM, a reconfigurable LSFM platform that enables high-resolution imaging across multiple spatial scales and refractive indices.

Aberrant pace of cortical neuron development in brain organoids from patients with 22q11.2 deletion syndrome-associated schizophrenia

This study identifies delayed cortical neuron development in 22q11.2DS-associated schizophrenia using brain organoids and single-cell RNA sequencing.

Capillary connections between sensory circumventricular organs and adjacent parenchyma enable local volume transmission

The paper identifies portal neurovascular connections between sensory circumventricular organs and adjacent brain tissue, enabling direct diffusible signaling.

Scalable projected Light Sheet Microscopy for high-resolution imaging of living and cleared samples

This paper introduces a cost-effective, scalable light sheet microscopy framework for high-resolution imaging of living and cleared samples, demonstrating its application on various biological samples.

Whole-brain mapping reveals the divergent impact of ketamine on the dopamine system

This study uses whole-brain mapping to show that chronic ketamine exposure reduces dopamine neurons in midbrain regions but increases them in the hypothalamus, with divergent effects on brain connectivity.