Aram Comjean

FlyPredictome scores 1.5 million AlphaFold-Multimer predictions of Drosophila protein pairs with a contact-aware integrated Local Interaction Score (iLIS), yielding residue-level interfaces enriched for phenotype-associated missense alleles.

DIOPT updates its ortholog prediction tool to include more species and algorithms, enhancing its utility for cross-species genomic analysis.

This study creates a Drosophila tauopathy model with the P251L mutation and uses single-cell RNA sequencing to identify molecular changes in neuronal and glial cells.

A Local Interaction Score (LIS), computed from AlphaFold-Multimer predicted aligned error, separates curated fly and human protein interactions from controls better than ipTM, recovering small or flexible interfaces.

The paper identifies a cholinergic pathway in Drosophila midgut regeneration that triggers Ca2+ waves to heal the epithelium and prevent chronic injury.

The paper shows that tumor-secreted cytokines induce hepatic gluconeogenesis, contributing to hyperglycemia and poor prognosis in cancer cachexia using Drosophila and mouse models.

PANGEA is a new GSEA tool that allows flexible analysis of gene sets using various annotations, enhancing visualization and comparison of results for Drosophila and other organisms.

This study develops an optogenetic model of muscle contraction in Drosophila larvae to investigate acute exercise-like responses and identifies transcriptional similarities between fly and human exercise-induced genes.

Paralog Explorer identifies candidate paralogs in model organisms and provides tools for their functional analysis.

FlyPhoneDB predicts cell-cell communication in Drosophila using scRNA-seq data by calculating interaction scores between ligand-receptor pairs.

The paper characterizes cell types in the fly kidney using snRNA-seq and identifies new clusters, markers, and signaling networks, linking them to mammalian and planarian kidney structures.

DRscDB provides a database for comparing scRNA-seq data across species, enabling searches for orthologous genes and cell type-specific expression patterns.

The paper shows that Drosophila muscle-derived Pvf1 signals to hepatocyte-like cells to suppress lipid synthesis and prevent obesity.

BioLitMine helps researchers find relevant biomedical literature by leveraging MeSH terms and gene annotations to improve search accuracy and identify co-cited genes and authors.

The paper updates TRiP's RNAi and CRISPR fly stocks, presenting over 5,000 CRISPR-OE and -KO stocks for gene activation and knockout studies in Drosophila.

The paper constructs a cell atlas of the adult Drosophila midgut using scRNA-seq, identifying 12 cell types and providing insights into their molecular features and functions.

The paper identifies genes involved in zinc detoxification in Drosophila cells through functional genomics and transcriptomics analyses, revealing key pathways and human disease-related gene orthologs.

Gene2Function integrates functional information of conserved genes across species into an online resource to aid in gene function discovery.

DGET provides a tool for querying and analyzing gene expression data in Drosophila, enabling researchers to compare expression across stages, tissues, and treatments.