Katherine E. Yutzey

Cardiomyocyte-expressed TGFβ signals to fibroblasts to program early heart maturation and adult myocyte identity

This study shows that TGFβ from cardiomyocytes programs fibroblast development and ECM environment to support cardiomyocyte maturation in the developing heart.

APOE-NOTCH Axis Governs Elastogenesis During Human Cardiac Valve Remodeling

The paper identifies a novel APOE+ elastin-producing valve interstitial cell subtype and reveals the APOE-NOTCH signaling axis regulates elastogenesis during human cardiac valve remodeling.

PROX1 inhibits PDGF-B expression to prevent myxomatous degeneration of heart valves

This paper shows that PROX1 inhibits PDGF-B expression in heart valves to prevent myxomatous degeneration, and PDGF-B inhibition ameliorates valve defects in mice.

Cardiomyocyte cell cycling, maturation, and growth by multinucleation in postnatal swine

This study examines cardiac maturation in postnatal pigs and mice, finding that pig cardiomyocytes undergo multinucleation and growth dynamics distinct from mice, with cell cycle arrest and loss of mononucleated-diploid cells occurring later.

SCAR FORMATION AND DECREASED CARDIAC FUNCTION FOLLOWING ISCHEMIA/REPERFUSION INJURY IN 1-MONTH-OLD SWINE

This study shows that 1-month-old pigs subjected to ischemia/reperfusion injury form a scar and do not regenerate myocardium despite cardiomyocyte cycling.