henhaobio
Sign in

bioRxivCancer BiologyPreprint

A new immunocompetent rectal cancer model to study radiation therapy

J. K. Kim, C. Wu, M. Del Latto, Y. Gao, S.-H. Choi, M. Kierstead, C.-E. G. Sauve, C. Firat, A. C. Perez, J. Sillanpaa, C.-T. Chen, K. E. Lawrence, P. B. Paty, F. M. Barriga, J. Shia, C. L. Sawyers, S. W. Lowe, J. Garcia-Aguilar, P. B. Romesser, J. J. Smith

PDFDOI

Abstract

We describe a new mouse model of rectal cancer (RC) involving rapid tumor organoid engraftment via orthotopic transplantation; the resulting RC tumors invaded inward from the mucosal surface and metastasized to distant organs. Histologically the tumors closely resemble human RC and mirror remodeling of the tumor microenvirnoment (TME) in response to radiation. This murine RC model thus recapitulates the pathogenesis of human RC, thereby fulfilling the need for a physiologically accurate model for preclinical efficacy studies.

Reproducibility ledger

Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.

Sign in to file a reproducibility report.

Related papers

Similarity Map
SelectedSame fieldCross-field
THISGanesh '19Tirado '20Kansal '24Xiao '25Wang '25Schmidt '22
79% semantic matchCancer Biology
K. Ganesh, C. Wu, K. P. O'Rourke+37 more·bioRxiv·May 22, 2019