comparative / phylogenetic analysis

This study uses spatial transcriptomics to analyze lesional skin from PG patients before and after IL-12/IL-23 blockade, revealing complex inflammation patterns and treatment-resistant B cell infiltration.

This study examines the evolution of Cdk4/6 and Cdkn2 in invertebrates, finding that Cdkn2 distribution is uneven and linked to Faf1, with conserved positive charge in Cdk4/6 in species with Cdkn2.

This study identifies convergent transcriptomic and genomic changes in xeric rodents, showing increased convergence with adaptation age and species relatedness.

This study examines skull evolution in Malagasy carnivorans, finding high disparity but no rapid lineage diversification, challenging adaptive radiation hypotheses.

This study uses computational models to show that psilocybin increases reward acquisition in rats by enhancing task engagement through altered forgetting rates and reduced loss aversion.

This paper designs a tunable protein filament that assembles in response to a peptide ligand and demonstrates its polarized growth and nucleation mechanisms.

The paper analyzes conserved noncoding elements in Caenorhabditis inopinata to identify evolutionary changes linked to its distinct morphological and behavioral traits.

This study manually annotates and refines gene models of the Toll pathway in 19 anopheline and 2 culicine mosquito genomes, revealing evolutionary constraints and radiation patterns.

This study identifies genomic signatures of domestication in a fungus farmed by leafcutter ants using long-read sequencing, revealing gene expansions and losses linked to cultivation adaptation.

This study investigates the evolutionary changes in LHCI structures across red-lineage algae, identifying conserved and diversified Lhcr groups and introducing the concept of neolocalization.

This study shows myosin-I enhances the force generation of Arp2/3 complex-nucleated actin networks by thinning them and promoting symmetry breaking.

This study investigates why holometabolous insects evolved a pupal stage, finding that rapid growth and a trade-off between growth and differentiation favor this life history under high mortality.

The paper identifies a novel expression domain of extradenticle in harvestman patella, suggesting that modification of an ancient gene, not neofunctionalization of a new copy, underlies the origin of the chelicerate patella.

The paper identifies instances of DNA polymerase (DNAP) swapping among bacteriophages, showing gene replacements between families and subfamilies without altering surrounding gene organization.

The paper tests whether rats use an integration strategy or degenerate strategies in a perceptual decision-making task and finds they predominantly use integration.

The paper proposes that the emergence of the Slc11 clade MCbgut in Lactobacillales was driven by a shift to manganese utilization, supporting their evolutionary adaptation in early vertebrate guts.

This study identifies two quorum-sensing systems in E. faecalis that regulate purine biosynthesis, enhancing its pathogenicity in macrophages and murine infections.

This study identifies cis-regulatory differences in the Mymk promoter that explain divergent muscle multinucleation patterns between vertebrates and tunicates.

The paper describes a new pararetrovirus found in an insectivorous bat, which forms a basal clade distinct from hepadnaviruses and nackednaviruses, suggesting ancestral non-enveloped pararetroviruses.

This study uses phylogenomic analyses to investigate the evolutionary history of Section Nintooa, revealing rapid radiation and reticulate evolution between Hainan, South China mainland, and Vietnam.

The paper tests if drought tolerance preceded frost tolerance in grasses but finds they evolved independently.

The paper uses coarse-grained simulations and unsupervised learning to study protein-mediated DNA compaction, finding that protein-protein interactions are critical for forming looped structures observed experimentally.

This study investigates the role of protein flavinylation in bacterial extracytosolic electron transfer by analyzing genomic, structural, and biochemical data.

The paper examines the evolution of the Doublesex gene in termites, finding structural and expression differences that may relate to caste development.

This study uses AlphaFold and RosettaCM to model 18 uncharacterized delta-conotoxins, providing structural insights and implications for drug development.

The paper studies the conservation and evolution of intrinsic transcriptional terminators between Escherichia coli and Salmonella enterica subsp. pullorum, finding low sequence and functional conservation despite their close relation.

This study analyzes discordant phylogenomic data from aphids to resolve their evolutionary history, finding monophyly of subfamilies but unresolved relationships between them.

This study shows that morphological traits, not socio-cognitive demands, are key predictors of brain size evolution in birds.

This study investigates how Dscam1 proteins evolved strict homophilic specificity through evolutionary intermediates that allowed promiscuous interactions.

This study investigates the genomic and cellular basis of biosynthetic innovation in rove beetles, identifying key genomic and cellular mechanisms underlying the evolution of defensive secretions.