imaging

Human brown adipose tissue demonstrates substantial 18F-fluorocholine uptake at room temperature for phosphatidylcholine synthesis

This study shows that 18F-fluorocholine PET can detect human brown adipose tissue at room temperature by measuring phosphatidylcholine synthesis, without requiring cold exposure.

Eg5 activity and density-driven bundling organize the human metaphase mitotic spindle independently of spindle bipolarity

The paper shows that Eg5 organizes antiparallel microtubule bundles in human metaphase spindles through density-driven steric interactions, independent of spindle bipolarity.

Multi-region two-photon calcium imaging in freely moving animals

This paper introduces MINI2P-II, a lightweight 2P miniscope enabling multi-region calcium imaging in freely moving animals with high resolution and dual-color capability.

Species-specific oculomotor control tolerances explain saccadic suppression strength differences between macaques and zebrafish

The paper compares saccadic suppression strength between macaques and zebrafish, showing it reflects differences in sensory and motor noise levels and computational resource allocation.

Neural Bases for Working Memory of Natural Sound Textures

The paper investigates how sound texture and loudness discrimination are affected by stimulus duration using behavioral and fMRI data, finding distinct neural correlates in auditory cortex and medial temporal lobe.

Effect of Neck Muscle Strength and Passive Cervical Viscoelasticity on Regional Brain and Axonal Tissue Response

This study assesses how neck muscle strength and cervical viscoelasticity affect brain motion, intracranial pressure, and axonal strain during head impacts.

Spontaneous neural activity in the developing ant olfactory system

This study investigates spontaneous neural activity in developing ant olfactory sensory neurons and finds stage-dependent patterns similar to mammals.

Intelligent SEEQPI enables reconstruction of inhibitory neuronal nuclei and dry-mass mapping deep in the living mouse brain

This paper introduces SEEQPI, a label-free imaging technique, to reconstruct inhibitory neuronal nuclei and estimate dry-mass density in deep brain regions of living mice.

Ratio-preserving super-resolution FLIM for quantitative live-cell lifetime imaging

This paper introduces SIM-fdFLIM, a super-resolution FLIM method that preserves ratio accuracy and enables high-speed, high-resolution live-cell lifetime imaging.

Bayesian in situ point spread function modeling enables high-fidelity three-dimensional nanoscopy in deep tissue

This paper introduces Bayesian in situ PSF modeling to improve 3D nanoscopy in deep tissue by accounting for optical distortions and uncertainties in PSF estimation.

Multiscale, Survey-and-Target Optical Super-Resolution Histology

This paper introduces MOSH, a multiscale optical super-resolution histology platform that enhances resolution while maintaining tissue-scale context and throughput.

Multi-region recordings reveal collapse of hippocampal CA3-amygdala gamma communication at seizure onset in mice

The paper uses multi-region recordings in mice to show that gamma communication between hippocampal CA3 and amygdala collapses abruptly at seizure onset.

DINOSim: Zero-Shot Object Detection and Semantic Segmentation on Microscopy Images

DINOSim detects and segments objects in microscopy images without annotated data, achieving performance comparable to supervised methods using a pretrained DINOv2 encoder and k-nearest neighbors refinement.

Claustrum Morphometry Reveals Spatially Heterogeneous Alterations in 22q11DS

The paper uses surface-based morphometry to analyze claustrum structure in 22q11DS, finding age-related shape changes and reduced deformation in the syndrome.

The elusive neural signature of emotion regulation capabilities: evidence from a large-scale consortium

This study examines the relationship between neural activation during reappraisal tasks and individual differences in emotion regulation, finding no shared overlap across three measures and highlighting methodological challenges in fMRI research.

Effect of Clover versus Zipping on Annular Geometry and Dynamics in Tricuspid Edge-to-Edge Repair

This study compares Clover and Zipping techniques in tricuspid edge-to-edge repair, finding that Clover reduces septal-lateral annular diameter more effectively.

Heightened gaze responsiveness and mutual gaze instability at close distances characterize dyadic coordination in a marmoset model of autism

This study examines dyadic coordination in a marmoset model of autism, finding heightened gaze responsiveness and unstable mutual gaze at close distances in affected pairs.

Eye gaze is not inversion-proof: A robust, sex-invariant gaze inversion effect

The paper investigates how face inversion affects sensitivity to gaze direction, finding a robust inversion effect that is largely sex-invariant.

A Smart Bait Dispenser with Real-time Monitoring for Species-Specific Bait Delivery

This paper develops a smart bait dispenser using image classification to deliver baits specifically to target species, achieving 75.6% bait delivery success with minimal non-target consumption.

Charting vulnerability of brainstem functional pathways in aging and prodromal synucleinopathy

This study maps brainstem-cortical connectivity in aging and prodromal synucleinopathy, finding distinct pathway vulnerabilities in each condition.

Quanta microscopy enables fluorescence imaging at the native bit-plane rate

Quanta microscopy enables high-speed fluorescence imaging at the native bit-plane rate by reconstructing multibit images from sparse photon-detection maps.

Causal reasoning is domain-specific in the human brain

This study investigates whether causal reasoning in the human brain involves a unified system or domain-specific regions, finding distinct brain networks for social and physical causal reasoning.

Dynamic merging of enhancer- and promoter-associated assemblies is coupled to transcriptional bursting

The paper uses live-cell imaging and analysis in mouse embryonic stem cells to show that transcriptional bursting is linked to dynamic merging of enhancer- and promoter-associated regulatory assemblies.

The global distribution of human-visible flower color diversity

The paper analyzes global flower color diversity using community science data, finding a latitudinal gradient in color diversity and associations with climate and pollination strategies.

Cortical asymmetry and its developmental change have distinct relationships with brain connectivity

This study examines how cortical asymmetry and its developmental changes relate to brain connectivity across three cohorts from birth to 22 years.

Ultrasonic Detection of Venous Gas Emboli and Tissue Gas in Rodents: Toward Imaging Biomarkers for Decompression Stress

This study uses ultrasound to detect venous gas emboli and tissue gas in rats after decompression, finding a correlation between gas emboli severity and decompression risk.

Absolute Quantification of Tissue Composition by Raman Spectroscopy

This paper introduces a method to quantify tissue composition using Raman spectroscopy, validated on cartilage with high accuracy compared to biochemical assays.

Cellular-resolution Three-photon Ultra-Deep Imaging (TrUDI) of neuronalpopulation activity at 2 mm depth in the mammalian brain

The paper introduces TrUDI, a three-photon microscopy system that improves imaging depth in the mouse brain to ~2 mm with enhanced fluorescence detection.

In situ pulse dispersion estimation via third-harmonic generation interferometric autocorrelation for multiphoton microscopy

This paper develops a method to estimate pulse dispersion in multiphoton microscopy using third-harmonic generation interferometric autocorrelation, demonstrating its effectiveness in vivo.

Astrocyte modulation of neural activity during intracortical microstimulation

This study shows astrocytes actively shape neural activity during intracortical microstimulation by modulating calcium signaling, influencing neuronal responses in a pattern-dependent manner.