Schizophrenia research and treatment

This study uses Mendelian randomization to explore the pleiotropic effects of education and intelligence on schizophrenia, finding that schooling years increase risk while intelligence decreases it, likely confounded by bipolar disorder.

The paper identifies genes and gene sets with increased expression variability in schizophrenia, linking this variability to genetic factors and brain development processes.

This study links higher brain glutathione levels to faster treatment response in first episode psychosis patients using 7-Tesla MRS.

This study finds that subthreshold psychosis symptoms in a population-based cohort are associated with genetic risks for schizophrenia, ADHD, autism, and neuroticism, with notable sex differences.

This study examines genetic correlations between psychotic experiences across age and with psychiatric disorders, finding significant overlaps with schizophrenia and depression.

The paper examines auditory processing differences in individuals with 22q11.2 Deletion Syndrome with and without psychotic symptoms compared to neurotypical controls using electrophysiology.

This study uses free-water imaging to find microstructural white matter differences in chronic schizophrenia patients compared to controls, with associations to subcortical structures and clinical symptoms.

The paper identifies CYP2D6 variants and expression features linked to schizophrenia risk using RNA-seq, GWAS, and epigenetic data.

The paper investigates how polygenic risk for schizophrenia interacts with childhood adversity to influence emotional dysregulation and psychosis proneness in adolescents and young adults.

The paper investigates glutamate levels and effective connectivity in the salience network of schizophrenia patients using multimodal imaging and cognitive tasks, finding links between glutamate and connectivity deficits.

The paper identifies differentially expressed genes in schizophrenia-associated neural progenitor cells, implicating WNT5A signaling in schizophrenia etiology.

This study shows that increased C4 expression in mice causes prefrontal cortex hypoconnectivity and reduced social interaction, linking C4 to schizophrenia pathogenesis.

The paper examines protein expression levels of prenyltransferase subunits in schizophrenia patients and finds decreased expression of FNTA, PGGT1B, and RABGGTB in the dorsolateral prefrontal cortex.

This study compares inhibitory processing in 22q11.2DS with and without psychotic symptoms, schizophrenia, and controls using EEG, finding reduced P3, Ne, and Pe responses, with P3 linked to severity and Ne/Pe to risk.

The paper examines abnormal processing of uncertainty in at-risk mental state individuals using computational models and fMRI, finding increased volatility estimates and altered cortical activation patterns.

The paper investigates how spatial frequency affects metacognitive performance in schizophrenia patients and controls, finding atypical SF dependence in patients.

This study investigates spatial suppression for motion in schizophrenia, finding weakened suppression and lower motion sensitivity, independent of IQ differences.

The paper examines cortical sulcation differences between schizophrenia patients and controls to determine the timing of prenatal insults, finding that schizophrenia-related disruptions predate cognitive deficits.

The paper examines reward processing in schizophrenia using ERPs, finding altered later reward outcome evaluation in early-stage patients and a link between brain age and depressive symptoms.

The paper identifies cardiovascular and infectious disease mechanisms linked to atypical antipsychotic side-effects using transcriptome analysis and bioinformatics.

The paper investigates visual contour perception and perceptual context effects in schizophrenia, finding impaired contour detection and weakened context suppression, with neural correlates in ERP components.

This paper conducts a systematic review and Bayesian meta-analysis of voice atypicalities in schizophrenia, identifying weak to moderate acoustic differences linked to negative symptoms and social impairments.

The paper links schizotypy-related magnetization in adolescent cortex to schizophrenia risk genes using MRI and gene expression data.

The paper identifies 40 genes with significantly altered expression in schizophrenia across three brain regions, linking them to neuronal function disruption.

The paper investigates how postnatal inactivation of the ventral subiculum in rats affects dopaminergic responses in the nucleus accumbens core after ketamine administration.

This study identifies schizophrenia genetic associations in East Asian and European populations, finding similar genetic effects across ancestries but highlighting challenges in polygenic risk prediction across groups.

This study shows that schizophrenia polygenic risk score predicts negative symptoms, cognition, and diagnostic shifts in psychotic disorders over 20 years.

This study examines structural connectivity diversity in schizophrenia using DTI, finding reduced topographic diversity in patients compared to controls, suggesting a common pathway underlying the disease's heterogeneity.

This study finds that schizophrenia patients show increased choice switching in reward-based tasks, linked to heightened beliefs about environmental volatility and greater prefrontal cortex activity.

The paper investigates whether healthy individuals with psychotic experiences show reduced auditory prediction errors and white matter microstructure, using EEG and MRI data.