Substance Abuse Treatment and Outcomes

Appetitive and aversive cue reactivities differentiate biotypes of alcohol drinkers

The paper identifies distinct neural circuits and biotypes in alcohol drinkers based on appetitive and aversive cue reactivity using fMRI data.

Differential momentary reports of stress and affect associated with alcohol consumption in middle-aged versus younger adults

This study compares stress and affect levels in middle-aged and younger adults during alcohol consumption and abstinence, finding age-related differences in stress reduction and affect.

Neural correlates of drinking reduction during cognitive behavioral therapy for alcohol use disorder

This study examines how cognitive behavioral therapy (CBT) for alcohol use disorder (AUD) affects brain activity in the dorsolateral prefrontal cortex (DLPFC) and reduces heavy drinking and craving.

Alcohol, Opioid, and Combined Alcohol and Opioid Use Disorders Affect Shared and Unique Pathways: A Proteomic Analysis of Postmortem Brains

This study identifies shared and unique proteomic pathways affected by alcohol, opioid, and combined substance misuse disorders using postmortem brain samples.

Desire and Craving ratings vary significantly for healthy alcohol consumers: Differences in semantic interpretation?

The paper investigates if healthy alcohol consumers rate alcohol desire and craving similarly using related descriptors, finding consistent differences in ratings during drinking, abstinence, and alcohol cue exposure.

Adolescent Binge Drinking is Associated with Accelerated Decline of Gray Matter Volume

This study examines how binge drinking affects gray matter volume decline in adolescents over time, finding stronger effects in younger individuals and suggesting potential for recovery with temporally proximal drinking.

Genetic Contributions to Alcohol Use Disorder Treatment Outcomes: A Genome-wide Pharmacogenomics Study

This study identifies genetic variants associated with AUD treatment outcomes using pharmacogenomic analyses of naltrexone and acamprosate responses.

Alcohol Use Disrupts Age-Appropriate Cortical Thinning in Adolescence: A Data Driven Approach

This study uses a data-driven method to show that alcohol use in adolescents affects cortical thinning differently across age groups.

Negative Urgency as a Risk Factor for Hazardous Alcohol Use: Dual Influences of Cognitive Control and Reinforcement Processing

The paper examines how negative urgency relates to hazardous alcohol use through cognitive control and reinforcement processing mechanisms using EEG data.

Alcohol cues elicit different abnormalities in brain networks of abstinent men and women with alcohol use disorders

This study uses fMRI to show gender differences in brain activation patterns in response to alcohol cues in abstinent individuals with alcohol use disorders.

An Integrated Multimodal Model of Alcohol Use Disorder Generated by Data-Driven Causal Discovery Analysis

The paper uses causal discovery analysis to build an integrated multimodal model of AUD, identifying key causal factors from brain function to social and affective factors.

Adolescent intermittent ethanol exposure induces sex-dependent divergent changes in ethanol drinking and motor activity in adulthood in C57BL/6J mice

This study shows that adolescent binge ethanol exposure leads to sex-dependent changes in ethanol consumption and motor activity in adult C57BL/6J mice, with males showing increased consumption and females showing decreased consumption and reduced center zone activity.

Gray and white matter morphology in substance use disorders: A neuroimaging systematic review and meta-analysis.

This study conducts a meta-analysis of VBM studies to identify gray and white matter morphology changes in substance use disorders, finding both convergent and divergent effects based on substance type and consumption severity.

Brain Anatomical Covariation Patterns Linked to Binge Drinking and Age at First Full Drink Prior to 21 Years

The paper identifies a reproducible structural brain pattern linked to age at first full drink before 21, using JIVE analysis on neuroimaging data from two datasets.

Hippocampal subfield volumes in abstinent men and women with a history of alcohol use disorder

The paper examines how alcohol use disorder, gender, age, and abstinence affect hippocampal subfield volumes in abstinent individuals.

Behavioural cue reactivity to alcohol and non-alcohol-related stimuli among individuals with severe alcohol use disorder: an fMRI study with a visual task

This study uses fMRI to compare brain responses to alcohol and non-alcohol-related cues in individuals with severe AUD and healthy controls, finding differences in BOLD responses to drinking-related images.

Alcohol Effects on Globus Pallidus Connectivity: Role of Impulsivity and Binge Drinking

This study examines how binge drinking affects globus pallidus connectivity and its relationship with impulsivity and drinking behaviors in humans.

Predicting future drinking among young adults:using ensemble machine-learning to combine MRI with psychometrics and behaviour

The paper uses ensemble machine learning to predict future drinking in young adults by combining MRI, psychometric, and behavioral data, finding that specific neuroimaging and non-neuroimaging factors are strong predictors.

LIBR Methamphetamine and Opioid Cue Database (LIBR MOCD): Development and Validation

The paper develops and validates a database of pictorial cues for methamphetamine and opioids, showing drug images elicit higher arousal and lower valence than neutral images.

Neurocognitive and psychiatric markers for addiction: Common vs. specific (endo)phenotypes for opiate and stimulant dependence

The paper examines neurocognitive and psychiatric traits in siblings with opiate or stimulant dependence to identify common and substance-specific endophenotypes.

Convergent evidence for predispositonal effects of brain volume on alcohol consumption

The paper identifies smaller brain volumes in the right dorsolateral prefrontal cortex and insula as predispositional risk factors for alcohol use, supported by genetic and longitudinal evidence.

Cue-reactivity and approach bias to social alcohol cues and their association with drinking in a social setting in young adults

The paper examines brain and behavioral responses to social alcohol cues and their link to drinking in a social setting, finding no significant association.

Alcoholism Gender Differences in Brain Responsivity to Emotional Stimuli

The paper examines gender differences in brain responsivity to emotional stimuli in individuals with and without alcoholism, finding reduced activation in alcoholic men and increased activation in alcoholic women in specific brain regions.

Measures of Possible Allostatic Load in Comorbid Cocaine and Alcohol use Disorder: Brain White Matter Integrity, Telomere Length, and Anti-Saccade Performance

The paper examines markers of allostatic load in individuals with comorbid cocaine and alcohol use disorders, finding associations between substance use duration and white matter integrity.

Exploring sex differences in the prevention of ethanol drinking by naltrexone in dependent rats during abstinence

This study evaluates how naltrexone affects ethanol drinking in male and female rats during different stages of abstinence, finding sex-specific and time-dependent effects.

Trajectories of Alcohol Use Initiation and Risk to Develop an Alcohol Use Disorder During Adolescence: A Role for Stress and Amygdala Activity

The paper identifies two trajectories of alcohol use initiation in adolescents and links early initiation to increased risk of AUD, stress, and amygdala reactivity.

Inhibition of Glyoxalase 1 reduces alcohol self-administration in dependent and nondependent rats

This study shows that inhibiting glyoxalase 1 with pBBG reduces alcohol self-administration in both dependent and nondependent rats, with greater effect in dependent animals.