Topic · Hepatology · Medicine
OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.
15 papers
R. Shastry, Aditya P. Kale, Sui Seng Tee
This study identifies proteomic and immune changes in hepatocellular carcinoma linked to cirrhosis severity, revealing a continuum of biological remodeling rather than discrete molecular states.
npj gut and liver. · Sep 2, 2026Peer-reviewedCancer Biology
Diwakar Suresh, Akshatha N. Srinivas, Bharathwaaj Gunaseelan, Amith Bharadwaj S. A., Manju Moorthy, Gopalkrishna Ramaswamy, Suchitha Satish, Prashant M. Vishwanath, Prasanna K. Santhekadur, Saravana Babu Chidambaram, Divya P. Kumar
This study shows that silencing AATF in the tumor microenvironment suppresses hepatocellular carcinoma growth by disrupting TGFβ signaling through the MIR100HG lncRNA.
Molecular Therapy Oncology · Jun 6, 2026Peer-reviewedCancer Biology
Chenicheri Kizhakkeveettil Keerthana, Tennyson Prakash Rayginia, Kalimuthu Kalishwaralal, Sandhini Saha, Nair Hariprasad Haritha, Amrutha Nisthul A., Mundanattu Swetha, Sreekumar Usha Devi Aiswarya, Lekshmi R. Nath, Sanjay Suresh Varma, Arun (Geetha) Viswanathan, Somaraj Jannet, Shirly J, Jayasekharan S. Aparna, Archana Praveen, , Ruby John Anto
This study shows that Uttroside B inhibits hepatocellular carcinoma and its pulmonary metastasis by blocking the EGFR/ERK pathway and its downstream targets SREBP-1 and STAT-3.
Cell Death Discovery · Apr 16, 2026Peer-reviewedCancer Biology
Ricardo Cuéllar Romero, Cinthia Toledo
The paper identifies conserved transcriptomic programs in HBV- and HCV-associated HCC, revealing opposing proliferation and hepatocyte-loss modules validated across cohorts.
In Silico Research in Biomedicine · Jan 1, 2026Peer-reviewedBioinformatics
Keyao Chen, Ahmet Toksoz, Colin Henchy, Jessica Knapp, Jie Li Lu, Sarangarajan Ranganathan, Huabo Wang, Edward V. Prochownik
This paper describes the generation of genetically-defined murine hepatoblastoma cell lines with angiogenic potential and reports their tumorigenic properties and drug sensitivities.
Cancers · Sep 14, 2025Peer-reviewedCancer Biology
Frédéric Saltel, Adèle Delamarre, Marie Decraecker, Jean‐Frédéric Blanc, Cyril Dourthe, Jean‐William Dupuy, Isabelle Mahouche, Nathalie Allain, Julie Giraud, Benoı̂t Pinson, P. Biolac-Sage, Jérôme Boursier, Paulette Bioulac-Sage, Anne‐Aurélie Raymond, Audrey Morisset, , Anne-Aurélie Raymond
This study identifies proteomic signatures predictive of treatment response in advanced hepatocellular carcinoma using mass spectrometry and machine learning.
ESMO Open · Sep 1, 2025Peer-reviewedCancer Biology
Mingdian Tan, Wei Ye, Yi Liu, Xiaowu Chen, Lakshmi Huttad, Mei‐Sze Chua, Samuel K. So
This study develops a niclosamide prodrug (NIC-PS) with improved bioavailability and shows it targets VASN-TGFβ signaling to reduce HCC tumor volume and enhance therapeutic responses.
British Journal of Pharmacology · Jul 22, 2025Peer-reviewedCancer Biology
Babak Khorsand, Nazanin Naderi, Seyedeh Sara Karimian, Maedeh Mohaghegh, Alireza Aghaahmadi, Seyedeh Negin Hadisadegh, Mina Owrang, Hamidreza Houri
This study identifies 125 consistently dysregulated genes across multiple HCC datasets, highlighting shared and unique molecular signatures associated with different etiologies.
Biochemistry and Biophysics Reports · Jul 1, 2025Peer-reviewedBioinformatics
Xiao Qian Xu, Hao Wang, Li-Chen Shi, Cheng Huang, Hong You, Jidong Jia, You-Wen He, Yuanyuan Kong
The paper identifies a 19-gene prognostic signature for hepatocellular carcinoma by analyzing stage-specific transcriptomic differences between super and poor survivors.
Journal of Digestive Diseases · Jul 1, 2025Peer-reviewedBioinformatics
Xubo Huang, Runya Fang, Yuqian Pang, Zhe Zhang, Jieru Huang, Yuting Li, Tao Yuan, Yun Zeng, Zhao Yao, Silvia Vega-Rubín-de-Celis, Josephine W. Thinwa, Qisheng Zhang, Hao Shen, Jiahong Wang, Feng Shen, Yongjie Wei
This study identifies HHLA2 as a ligand-independent activator of c-Met in HCC, showing its role in tumor progression and its predictive value for c-Met inhibitor response.
Journal of Experimental & Clinical Cancer Research · May 20, 2025Peer-reviewedCancer Biology
Kah Keng Wong, Suzina Sheikh Ab Hamid
This study identifies TM4SF4 as a promising cell surface target in hepatocellular carcinoma through multiomics analysis of gene expression and protein data.
PLoS ONE · Feb 25, 2025Peer-reviewedCancer Biology
Elizabeth S. Borden, Annika Jorgensen, Heini M. Natri, Karen Taraszka Hastings, Kenneth H. Buetow, Melissa A. Wilson
This study compares transcriptomic and immune profiles of HBV- and HCV-mediated HCC, finding convergence in tumor landscapes despite differences in adjacent tissue and highlighting sex sampling limitations.
Human Genetics and Genomics Advances · Oct 19, 2024Peer-reviewedGenetics
Xiaofan Lu, Jialin Meng, Haitao Wang, Yujie Zhou, Jian‐Guo Zhou, Xinjia Ruan, Yi Chen, Yuqing Ye, Liwen Su, Xiaole Fan, Hangyu Yan, Liyun Jiang, Fangrong Yan
The paper develops a DNA replication stress-related prognostic index for HBV-associated HCC using machine learning, identifying therapeutic targets and agents for high-risk patients.
The Innovation Medicine · Jan 1, 2023Peer-reviewedBioinformatics
Heini M. Natri, Melissa Ann Wilson, Kenneth H. Buetow
This study identifies sex-specific gene expression and eQTL differences in hepatocellular carcinoma, revealing distinct molecular mechanisms driving male and female HCC.
BMC Cancer · Oct 15, 2019Peer-reviewedGenomics
Kumardeep Chaudhary, Olivier Poirion, Liangqun Lu, Lana X. Garmire
This paper develops a deep learning model integrating multi-omics data to predict survival in liver cancer, identifying two patient subgroups with significant survival differences.
Clinical Cancer Research · Oct 5, 2017Peer-reviewedBioinformatics