Inflammatory Bowel Disease

This paper develops a subcutaneous colon-specific immune niche to treat ulcerative colitis, showing it reduces inflammation and prevents cancer in mouse models.

This study shows that AIEC colonization in a larval zebrafish model worsens DSS-induced colitis and prevents mucosal recovery.

This study examines how chronic gut inflammation in IBD affects brain dynamics using EEG, finding altered brain states and connectivity patterns in CD and UC patients.

The paper identifies a shared B cell response to a conserved flagellin epitope in Crohn's disease patients and healthy infants, suggesting a potential early failure of homeostatic immunity.

The paper identifies two novel CD susceptibility loci and reports an epistatic interaction between variants in the LILR and TAP2 loci.

This study shows that a multimineral intervention reduces inflammation and improves barrier function in human colon organoids exposed to pro-inflammatory stimuli.

The paper identifies four IBD-associated genes that regulate calprotectin expression in myeloid cells and shows their role in prostaglandin signaling pathways linked to IBD susceptibility.

This study identifies genetic heterogeneity in ulcerative colitis by analyzing genome-wide associations in mild and severe cases, finding distinct risk variants and a genetic risk score with no difference between mild and severe disease.

The paper identifies ten new genes with coding variants linked to Crohn's disease risk using sequencing data from over 30,000 patients and 80,000 controls.

The paper identifies hyperactive chemotaxis and IL13RA2 as factors contributing to anti-TNFα treatment resistance in IBD.

The paper functionally screens IBD genes in intestinal epithelial cells to identify their roles in epithelial structure and function, revealing DUSP16's role in mucosal defense.

This paper identifies a genetic variant associated with primary non-response to anti-TNFα therapy in IBD patients and links it to increased TNF secretion through autophagy mechanisms.

The paper identifies differentially expressed smRNA in fecal exosomes of IBD model mice, suggesting their potential as early diagnostic markers for inflammatory bowel disease.

The paper identifies recessive NOD2 inheritance as a major driver of early onset Crohn’s Disease in both pediatric and adult cohorts.

This study identifies shared and ethnicity-specific HLA associations with ulcerative colitis through trans-ethnic analysis of diverse populations.

This study identifies clarithromycin as a potential therapeutic for inflammatory bowel disease through in-silico drug repositioning and experimental validation of its effects on NF-κB signaling.

The paper investigates how intestinal inflammation in IBD affects SARS-CoV-2 entry receptors like ACE2, finding opposing regulation in ileum and colon.

The paper develops a translation model to identify integrin signaling in anti-TNF-resistant Crohn’s disease and validates it using single-cell RNA sequencing.

The paper analyzes somatic mutations in colonic crypts of IBD patients and controls, finding higher mutation rates and clonal expansions in IBD-affected tissue.

This study shows that Runx3 in mononuclear phagocytes prevents colitis by promoting anti-inflammatory differentiation and suppressing pro-inflammatory gene expression.

The paper examines tau expression and phosphorylation in Crohn's disease and ulcerative colitis, finding upregulated tau isoforms in Crohn's disease via reduced protein clearance.

This study finds high serum elafin levels are linked to intestinal strictures in Crohn’s disease patients, suggesting elafin could be a biomarker for identifying strictures.

This study identifies HLA-DQA1*05 as a genetic risk factor for anti-drug antibody development in Crohn's disease patients treated with anti-TNF therapies.

This paper introduces AVA,Dx, a machine learning method using whole exome sequencing to predict Crohn's disease status with 71% precision and 73% recall.

This study identifies key genes and pathways associated with Crohn's disease using bioinformatics analysis of gene expression data from public datasets.

The paper identifies 9 urinary proteins differentially expressed in a TNBS-induced colitis rat model, with 3 previously linked to IBD and 6 newly discovered.

The paper re-analyzes proteomics data from ulcerative colitis colon biopsies, confirming NET upregulation and identifying ECM degradation and neutrophil maturation as novel pathological features.

This study identifies miR-31 as a marker that stratifies Crohn’s disease patients into two subtypes with distinct clinical outcomes.

The paper identifies a rare variant in the NLRP7 gene associated with increased risk of ulcerative colitis through exome sequencing and genotyping in IBD families and cohorts.