Antibiotic Resistance in Bacteria

The paper analyzes the genetic diversity and functionality of rmpADC variants in Klebsiella pneumoniae to understand their role in virulence and antimicrobial resistance.

This study identifies four colistin-resistant Acinetobacter seifertii strains from tank milk, revealing lipidomic differences and potential resistance mechanisms not seen in A. baumannii.

The paper tests the effect of 2,4-Dinitrophenol on multidrug-resistant bacteria and finds it inhibits growth but shows variable MICs, suggesting complex interactions.

The paper develops an open-source, cloud-based tool for detecting pathogens and antimicrobial resistance genes in metagenomic and whole-genome sequencing data, demonstrating its application across clinical and environmental studies.

The paper reports the first detection of OXA-48-like carbapenemase genes in clinical Enterobacterales from Guatemala, indicating their circulation since 2019.

The paper uses long-read sequencing to analyze plasmids in carbapenemase-producing Enterobacterales isolates, revealing plasmid diversity and potential outbreaks across UK hospitals.

hAMRonization standardizes AMR gene detection outputs from multiple tools into a unified format for easier analysis and integration.

This study finds high prevalence of Class 1 integrons in carbapenem-resistant E. coli in Nepal, often co-occurring with carbapenemase genes like blaNDM-1.

ReGAIN identifies and maps resistance gene networks in bacterial pathogens using Bayesian networks, providing insights into co-occurrence patterns and antimicrobial resistance dynamics.

This study shows that capsule production in Acinetobacter baumannii affects adhesion to surfaces and natural transformability, highlighting a trade-off in virulence and genetic adaptability.

The paper characterizes multidrug-resistant and ESBL-producing E. coli and K. pneumoniae in maternal and neonatal colonization in a Cameroonian labour ward, finding high prevalence of MDR isolates and blaCTX-M gene.

This study shows combining cefiderocol with aztreonam delays resistance development in NDM-producing E. cloacae complex isolates, with a 4-fold MIC reduction being a key predictor.

This study uses dual RNA-sequencing to analyze transcriptomic changes in Acinetobacter baumannii and human macrophages under polymyxin B treatment, revealing key stress response mechanisms and potential therapeutic targets.

The paper introduces a novel index, FOGS, to measure bacterial genome plasticity by incorporating time and gene transfer events, showing higher FOGS in high-risk clones.

This study identifies white storks as a model system to explore the ecology of Acinetobacter baumannii, revealing its environmental reservoirs, seasonality, and genetic diversity across Europe.

The paper characterizes iuc3-carrying plasmids in Klebsiella pneumoniae isolates, identifying convergent plasmids with resistance and virulence genes and highlighting their global epidemiology.

ClonalTracker identifies dissemination patterns between vancomycin-resistant Enterococcus faecium isolates by analyzing genomic features and provides results on a public webserver and GitHub.

This study introduces GeneBac, a deep learning model that predicts antibiotic resistance from bacterial genomic sequences, showing accurate MIC prediction and variant effect assessment.

This study identifies unique pathogenic markers in Klebsiella pneumoniae through multi-omics analysis, suggesting potential novel antimicrobial targets.

This study characterizes genomic, epigenomic, and transcriptional resistance mechanisms in carbapenem and colistin-resistant Klebsiella pneumoniae and Enterobacter isolates.

This study examines collateral effects of daptomycin resistance in E. faecalis, revealing diverse phenotypic outcomes and trade-offs in drug resistance and growth.

MOBFinder classifies plasmid metagenomic fragments into MOB categories using natural language models, achieving higher accuracy than existing tools.

This study uses high-throughput evolution to explore antibiotic resistance landscapes in E. coli exposed to low-level antibiotics, identifying key mutations and developing predictive models.

This study reviews whole-genome sequencing of AMR pathogens in India, finding limited diversity in sequenced strains and lack of environmental and travel-related studies.

The paper identifies a pan-resistant Pseudomonas aeruginosa strain with GES in California and assesses its treatment using a translational murine model.

This study uses nanopore sequencing to identify antimicrobial resistance genes, mobile genetic elements, and virulence factors in clinical isolates from Kenya, revealing widespread resistance and genetic determinants.

This study identifies panC as a therapeutic target in OprD-deficient Pseudomonas aeruginosa by showing its role in growth and virulence through transposon sequencing and CRISPRi.

This study identifies a carbapenem-resistant Pseudomonas aeruginosa strain co-harboring blaKPC-2 and blaVIM-2 genes, revealing their genetic environment and plasmid-mediated transmission.

The paper identifies a Tn7-like transposon carrying blaIMP-1 in carbapenem-resistant Pseudomonas aeruginosa strains and describes its genetic structure and potential role in intrahospital dissemination.