Mosquito-borne diseases and control

The paper analyzes cytokine profiles in dengue-infected patients from Northeast India, finding elevated Th1/Th2 cytokines and sex-specific regulation of anti-inflammatory cytokines.

This study uses scRNA-seq to compare transcriptomic responses of DENV-infected and bystander macrophages under ADE and conventional infection, revealing distinct gene expression patterns and pathways.

This paper validates modified ISA strategies for producing synthetic JEV and WNV DNA fragments, enabling efficient and bacteria-free synthesis of flaviviruses.

This study creates a single-cell atlas of Culex tarsalis midgut cells during West Nile virus infection, revealing cell-type-specific differences in viral replication and immune responses.

This paper introduces BuzzWatch, a platform to monitor mosquito behavior over weeks, revealing differences in activity patterns and responses to environmental and physiological factors.

This study analyzes global Culex blood-feeding data to show that feeding patterns vary between species and regions, influenced by external factors rather than phylogeny.

This paper analyzes the 2018 Usutu virus outbreak in common blackbirds in France using surveillance networks and population data to identify spatial patterns and population impacts.

This study presents the cryo-EM structure of immature dengue serotype 2 VLPs and uses MD simulations to reveal their maturation mechanism and lipid dependency.

The paper investigates the virome of Aedes mosquitoes near the DRC-Angola border, finding evidence of dengue virus transmission and a diverse virome including other viruses.

This study shows that repeated blood feeding during drought increases mosquito survival and viral transmission potential by enhancing activity and CO2 sensing.

This paper develops a CRISPR knockout screening method using viral replicons to identify host factors essential for viral replication, successfully identifying known and novel genes for dengue, chikungunya, and Ebola viruses.

This study shows that elevated temperatures below the lethal limit reduce Aedes aegypti fertility, with effects persisting across generations and being exacerbated by adult exposure to high temperatures.

This paper reviews genetic factors influencing prenatal brain injury from Zika virus, identifying 23 genes, 6 maternal and 17 fetal, that modulate susceptibility to neurological outcomes.

This study assesses mosquito and Stegomyia indices across urban-rural gradients in Cocody-Bingerville during dengue outbreaks, finding higher risks in urban areas dominated by Aedes aegypti.

The paper identifies three novel jingmenviruses with up to six genomic segments and proposes mechanisms for their translation, contributing to understanding their multipartite genomic organization.

This paper reviews the use of viral metagenomics in detecting arboviruses in mosquitoes, finding it effective in identifying viral diversity and pathogenic viruses.

The paper analyzes DENV-1 genotype V genetic diversity and spread in western Colombia, finding local dispersion and evolution rather than introduction of a new lineage.

This study shows that ZIKV envelope glycosylation mutants V153D and N154D, selected in Rag1-/- mice, replicate more efficiently in vitro and in organoids, suggesting N-linked glycosylation is not essential for envelope folding and trafficking.

This study analyzes DENV-3 genomes in Brazil to identify multiple introductions of the 3III_B.3.2 lineage and trace its spread from the Caribbean and Costa Rica.

This study identifies CNPY3 as an antiviral mediator suppressed by flaviviruses via HuR-mediated mRNA destabilization and demonstrates LNP-CNPY3 as a therapeutic approach to enhance antiviral responses.

The paper determines the cryo-EM structure of immature, small VLPs of dengue virus type 2, revealing octahedral symmetry and prM-E heterodimer clustering, with implications for vaccine design.

Craft is a machine learning framework for dengue subtyping that achieves high accuracy and speed, outperforming existing tools in classification efficiency.

The paper introduces Molecular Xenomonitoring (MX) to detect West Nile and Usutu viruses in mosquito populations, showing it can identify viral circulation before human cases.

This paper uses machine learning to predict dengue serotypes from antibody titre data, achieving 80.6% accuracy with spatiotemporal data.

The paper reports the first detection of Culex pipiens in Alberta, Canada, identifies the dominant ecotype as form pipiens, and notes a trend of increased form pipiens in northern latitudes.

This study evaluates an insect-based chimeric virus vaccine against Chikungunya fever, showing rapid and durable protection in macaques.

The paper identifies gaps in genomic surveillance of West Nile Virus in Africa and proposes strategies to improve public health response.

This study assesses the spread of Aedes aegypti and Aedes albopictus in Cyprus using spatial networks, dynamical models, and R0 analysis to evaluate public health risks in the Eastern Mediterranean.

This study demonstrates that liver homogenates can effectively detect neutralizing antibodies against arboviruses in non-human primates, offering an alternative to traditional serum-based serological tests.

The paper examines how different forest edge landscapes affect mosquito communities and pathogen emergence risk in the Amazon rainforest.