Hearing, Cochlea, Tinnitus, Genetics

The paper was withdrawn due to lack of full author consent and will not be cited as reference.

The paper develops a flexible mechanical model of the organ of Corti to study how vibrations are transmitted from the basilar membrane to inner hair cells, highlighting cooperative interactions that enhance frequency selectivity and signal amplification.

This study investigates how noise trauma and high-frequency stimulation affect sensory gating in the thalamic medial geniculate body of rodents, finding that HFS reduces evoked potential amplitudes in noise-exposed animals.

The paper introduces a novel stimulus paradigm to simultaneously record monaural and binaural frequency following responses to identify the binaural interaction component.

The paper investigates noise invariance in inferior colliculus neurons under different noisy conditions and finds that non-stationary noise uniquely affects neural activity, while white and natural stationary noises produce variable responses.

This study investigates the impact of maternal licking and grooming on auditory development and brain gene expression in Wistar rat pups, finding no effect on hearing onset timing but revealing insights into auditory periphery development and gene regulation.

This study shows that radixin is essential for cochlear amplification by modulating stereocilia function and sound-evoked electrical potentials in guinea pigs.

This study shows outer hair cells can either amplify or suppress vibrations in the organ of Corti, affecting cochlear frequency tuning.

The paper identifies differences in hair cell biology and behavior in zebrafish myo7aa-/- mutants and shows that L-type voltage-gated calcium channel agonists can rescue these phenotypes.

The paper investigates how tinnitus arises by examining anticipatory auditory predictions in individuals with and without tinnitus using MEG data.

This study investigates how high-intensity sound exposure inhibits hippocampal long-term potentiation (LTP) by reducing brain-derived neurotrophic factor (BDNF) levels and shows that BDNF or TrkB agonists can reverse this effect.

This study maps mouse and human cochlea development using single-cell RNA-sequencing and a new clustering algorithm, identifying new cell types and gene associations related to hearing loss.

The paper shows that immature inner hair cells in the cochlea have intrinsic Ca2+ action potentials that are bidirectionally coupled to ATP-dependent Ca2+ signaling in non-sensory cells.

The paper investigates the functional role of dendrites in MNTB neurons, finding that dendritic growth reduces EPSP decay time, enhancing signal precision.

The paper investigates abnormal connectivity in the right parietal operculum 3 (OP3) in acoustic trauma tinnitus using seed-based resting-state fMRI, finding specific connections with the premotor ear-eye field and inferior parietal lobule.

This study shows let-7 miRNAs limit pro-sensory cell self-renewal and regulate HC differentiation by targeting CHD7 in the vertebrate inner ear.

The paper examines how single units in the LSO of decerebrate cats respond to sinusoidally amplitude modulated tones, showing strong synchronization to low modulation frequencies and changes in discharge rate with sound level.

The paper investigates the role of lateral superior olive (LSO) in the inferior colliculus (ICC) by inactivating LSO and observing changes in ICC unit responses, finding that type I units are primarily driven by LSO.

The paper investigates how noise exposure alters the cochlear proteome in mice, identifying proteostasis responses and proteins involved in regeneration and mitochondrial dysfunction in noise-induced hearing loss.

This study identifies Brg1's role in specifying neurosensory lineage and differentiation in the mammalian inner ear by interacting with Eya1/Six1 and regulating chromatin structure.

This study identifies Activin A signaling as a regulator of hair cell differentiation and terminal mitosis gradients in the mammalian cochlea.

This study shows that gap detection thresholds remain stable in aged mice with preserved peripheral hearing, suggesting peripheral, not central, processing determines this task.

This paper conducts a GWAS on the Hybrid Mouse Diversity Panel to identify genetic loci associated with noise-induced cochlear synaptopathy and identifies 4 novel loci and candidate genes.

This study uses rs-fMRI to compare spontaneous neural activity in tinnitus patients with and without hearing loss, finding distinct mALFF patterns in the central auditory system.

This study investigates whether TRPV5, TRPV6, TRPM6, and TRPM7 contribute to hair-cell mechanotransduction and finds they are unlikely to be the pore-forming subunit of the transduction channel.

This study compares age-related declines in behavioral AMF discrimination and EFRs in rats, finding greater perceptual deficits than neural response declines.