Hearing, Cochlea, Tinnitus, Genetics

Ascending inputs to inferior colliculus subdivisions reveal pathway-specific hybrid organization in the external cortex

The paper maps ascending inputs to subdivisions of the mouse inferior colliculus, revealing that the external cortex has a hybrid input organization combining features of both core and shell regions.

Otoprotective effect of MnTBAP in cisplatin-induced hearing loss

This study investigates the protective effect of MnTBAP against cisplatin-induced hearing loss in mice, showing it prevents hearing threshold elevation and cellular damage.

Rocking Without a Tune: Ex vivo and in vivo Responses to Sound in the Basilar Papilla of the Tokay Gecko

This study examines sound-evoked mechanical responses in the tokay gecko's basilar papilla, finding untuned rotational motion and proposing anatomical asymmetry as a mechanism for auditory tuning.

Epithelial-Mesenchymal Wnt Crosstalk Directs Planar Cell Polarity in the Developing Cochlea

The paper investigates the role of Wnt signaling in cochlear development, showing that Wnt proteins from both epithelial and mesenchymal compartments guide cochlear outgrowth and hair cell polarization, with redundancy across compartments.

Brain-wide mapping of neuroanatomical connections to the auditory cortex of hearing and deaf mice

The paper maps brainwide connections to the auditory cortex in deaf and hearing mice, finding reduced inputs from specific regions in deaf mice but preserved connectivity in others.

Hyperpolarization-activated cation channels confer tonotopic specialization for temporal encoding of sound frequency in the cochlear nucleus

The paper identifies a tonotopic gradient of hyperpolarization-activated cation channels (IH) in the nucleus magnocellularis that enhances temporal encoding of sound frequency.

Electrophysiological profiling of exocytosis during early-stage development of the zebrafish lateral line

The paper uses electrophysiological recordings to study exocytic properties of zebrafish lateral line hair cells during development, finding no positional variation but reduced capacitance in tail-region cells and a role for otoferlin b.

Heat-shock pathway activation by TRC051384 protects spiral ganglion neurons from noise-induced hearing loss

TRC051384, an Hsf1 activator, protects spiral ganglion neurons from noise-induced hearing loss by restoring proteasome function and preserving synapse density.

Aging Alters Hair Cell Physiological Properties in Mice with Late-Onset Age-Related Hearing Loss.

This study shows that hair cell function declines with age in mice before hearing loss is detectable, challenging the idea that stereocilia are the most fragile part of sensory cells in aging.

A Novel Central-Peripheral Interface: The Auditory Nerve Glial Transition Zone Exhibits Enhanced Age-Related Immune and Glial Cell Dysfunction

This study identifies the auditory nerve glial transition zone as a critical site of age-related immune and glial dysfunction contributing to hearing loss.

PALM3 and hearing loss: a potential dual diagnosis interfering with novel gene discovery

The paper identifies a homozygous splice-site variant in PALM3 and a missense variant in OTOA in a family with autosomal recessive hearing loss, supporting PALM3 as a candidate gene through functional and comparative analysis.

An Objective Detection Method for Tinnitus using Memristors

This paper develops a memristor-based method to objectively detect tinnitus using serum from human and mouse samples, showing high discrimination between tinnitus and non-tinnitus individuals.

Genetic Targeting and Conductance-Based Modeling Reveal Novel Diversity Within Mouse Type II Spiral Ganglion Neurons

This study identifies biophysical and ion channel diversity in mouse type II spiral ganglion neurons using genetic tools and computational modeling, revealing distinct subtypes with potential functional differences.

Peripheral phoneme encoding and discrimination in aging and hearing impairment

The paper examines how aging and hearing impairment affect speech encoding and phoneme discrimination using EEG and behavioral tests, finding age-related declines in high-frequency envelope coding but preserved low-frequency encoding.

Molecularly defined auditory neuron subtypes show different vulnerabilities to noise- and age-related synaptopathy in mice

The paper identifies auditory neuron subtypes in mice and shows that Ia neurons are more resilient to noise and age-related synaptopathy than Ib/Ic neurons.

In-ear-tACS: Auditory Perception and Side Effects depend on Electrode Montage, Frequency, and DC-Offset

This study investigates tACS parameters for cochlear stimulation, finding that frequencies between 250 Hz and 2000 Hz reliably elicit auditory impressions with minimal side effects.

Hair Cells Loss Estimation from Audiograms

This paper develops a framework to estimate hair cell loss from audiograms using a cochlear model and validates it against existing data.

Computational model for synthesizing auditory brainstem responses to assess neuronal alterations in aging and autistic animal models

The paper develops a computational model to synthesize auditory brainstem responses (ABRs) and links ABR morphology changes to neuronal alterations in aging and autism animal models.

Tonotopically distinct OFF responses arise in the mouse auditory midbrain following sideband suppression

This study shows that hearing loss alters spatiotemporal neural activity patterns in the mouse auditory midbrain, specifically abolishing sideband suppression and tdOFF responses, which may contribute to tinnitus and hyperacusis.

From Chewing to Chirping: The Misophonia Audiovisual Trigger Archive (MATA)

The paper introduces MATA, a large audiovisual stimulus archive for misophonia research, enabling systematic study of emotional and physiological responses to misophonic triggers.

Live imaging and multimodal profiling reveal transdifferentiation of a cochlear supporting cell subpopulation upon Notch inhibition

The paper identifies a rare subpopulation of cochlear supporting cells that transdifferentiate into hair cells upon Notch inhibition, revealing epigenetic and transcriptional changes associated with this process.

Characterizing Simultaneously Recorded Auditory Brainstem and Middle Latency Responses Using the Parallel Auditory Brainstem Response Paradigm

The paper evaluates simultaneous recording of auditory brainstem and middle latency responses using the parallel ABR paradigm, finding that specific waves are consistently identifiable and robust across conditions.

Tonotopic Specialization of MYO7A Isoforms in Auditory Hair Cells

The paper identifies a novel MYO7A isoform, MYO7A-N, and shows its distinct expression and function in outer hair cells, contributing to hearing sensitivity and cochlear frequency resolution.

HSD17B7 is required for the function of sensory hair cells by regulating cholesterol synthesis

This study identifies HSD17B7 as critical for sensory hair cell function by regulating cholesterol synthesis, showing its role in auditory physiology and hearing loss.

Temporal dynamics of neuroplasticity and neurodegeneration in the central auditory system following noise-induced hearing loss: A multimodal imaging and histological study

Trial-By-Trial Auditory Brainstem Response Detection

This paper introduces a method to classify individual auditory brainstem response (ABR) trials as detected or undetected, revealing stochastic signal detection in the brainstem across stimulus levels.

Discovering age- and sex-specific genetic risk factors in sensorineural hearing loss: genome-wide evidence from large-scale biobank studies

This study identifies 32 new SNHL risk loci through genome-wide meta-analyses of 531,059 individuals, including age- and sex-specific differences.

Potential risk for hearing from prolonged exposure to sound at conversation levels

This study shows that prolonged exposure to conversational-level sound can impair hearing in mice, as indicated by changes in auditory brainstem response (ABR) metrics.

Lack of Oncomodulin Increases ATP-Dependent Calcium Signaling and Susceptibility to Noise in Adult Mice

This study shows that lack of oncomodulin in adult mice increases ATP-dependent calcium signaling and susceptibility to noise-induced hearing loss.

Bone conducted responses using the parallel auditory brainstem response (pABR) paradigm

This study confirms the feasibility of bone conduction pABR by comparing waveforms and thresholds with air conduction in young adults with normal hearing.