Immune Response and Inflammation

This study shows how small variations in LRR repeats of human TLRs lead to structural and functional diversity, enabling recognition of different ligands and immune responses.

The paper shows hypoxia reduces IFN-α secretion from PDCs but preserves their production capacity, mediated by soluble factors and cell contact mechanisms.

The paper shows chicken-specific ERVs activate MARCO-mediated TLR3-IL-1β inflammatory response to block exogenous retrovirus infection.

This study shows that Peucedanol reduces inflammation in LPS-treated cells and sepsis in mice by inhibiting the TLR4/myD88/NF-κB pathway and improving intestinal flora.

The paper analyzes the sequence and structural features of TLR4 adaptors to understand their evolutionary development and functional roles across species.

This study identifies how S100A9 interacts with CD14 to activate TLR4, showing CD14-dependent TLR4 internalization and a dynamic binding site on CD14 that overlaps with LPS binding.

The paper shows macrophages use TLR4 memory and IL-10 susceptibility gating to adjust inflammation based on pathogen dynamics.

This study uses metabolomics to show that palmitic acid alters N-glycosylation-related metabolites in THP-1 macrophages, linking them to TLR4 activation and inflammation.

This study shows IRAK4 auto-phosphorylation activates IRAK oligomerization, controlling inflammatory signaling by promoting DD domain assembly and downstream IL-1 signaling.

The paper shows host-derived oxidized phospholipids initiate effector-triggered immunity, leading to lethality upon microbial encounter, and demonstrates that blocking oxPLs reduces inflammation and host death.

This study identifies STK25 as a kinase that phosphorylates IRF5, enhancing TLR7/8-mediated inflammation in human and murine immune cells.

The paper investigates how mitochondrial genes cytochrome B and C contribute to immune response against Duck Pasteurellosis through nuclear gene-mediated mechanisms.

This study shows that LPCAT2 regulates CD14 expression in macrophages, affecting their inflammatory response to E. coli O111:B4.

The paper investigates the antiviral potential of duck immune response genes TLR3, TLR7, and RIGI against Avian influenza using in silico molecular docking.

The paper investigates the structural and functional properties of LRRs in TLR1 subfamily members through phylogenetic analysis, chimera creation, and molecular dynamics simulations.

This study investigates how pathological mutations affect the prion-like polymerization of MyD88, showing that these mutations block polymerization and alter oligomer stability.

This study compares THP-1 monocyte responses to various pathogens using transcriptomics to provide insights for improving experimental design.