Cellular Mechanics and Interactions

This paper introduces an open-source stretching system for simultaneous mechanical and structural analysis of soft materials and biological tissues.

The paper tests low-intensity vibration to enhance cell proliferation in biomanufacturing, showing it can be tailored to different cell types to improve yields.

The paper shows that mechanical and biochemical feedbacks combine to create complex contractile oscillations during cytokinesis.

This study investigates the interplay between formins and Arp2/3 complex in cortical actin wave dynamics, revealing both cooperation and antagonism regulated by Cdc42.

This study compares Brillouin microscopy and AFM-based indentation to assess mechanical properties of murine retinal tissues, finding divergent results and highlighting their complementary nature.

This paper introduces a label-free optical mapping platform for large-area biomechanical dynamics of multicellular systems, achieving high spatiotemporal resolution and long-term observations.

This study shows that histoblasts in Drosophila undergo a mechanical transition from tension to buckling, leading to their jigsaw puzzle shape during larval development.

This study develops a mathematical model to simulate how differential proliferation and mechanical interactions influence embryonic axial extension across multiple tissues.

This study shows that Th1 T cells use integrin-mediated focal adhesions to migrate through confined environments by pulling themselves forward.

This paper describes how curved crease origami and topological singularities enable hyper-extensibility in the protist Lacrymaria olor, linking geometry to cellular morphodynamics.

This study identifies LUZP1 as a regulator of actomyosin bundle assembly, showing its role in myosin II filament concatenation and stress fiber formation.

The paper introduces a transgenic Lifeact-EGFP quail line for live imaging of actin dynamics during avian embryogenesis and demonstrates its utility in studying cellular protrusions and supracellular actin structures.

This study uses an ovarian tumor-on-chip to investigate how extracellular matrix and shear stress influence tumor cell migration and phenotype, showing ECM's dominant role in migration modes and EMT transition.

This study shows that Arabidopsis seeds undergo anisotropic and isotropic growth phases driven by distinct mechanical responses in different layers of the seed coat.

This paper introduces a high-throughput method for quantitatively measuring mechanical properties of biological samples using parallel micropipettes.

This study shows that substrate stiffness anisotropy guides myotube alignment through collective cellular dynamics in C2C12 myoblasts.

The paper investigates spatiotemporal fluctuations in plant tissue growth, showing that growth couples temporal and spatial variations through a mechanism called fluctuation stretching.

The paper models how cell footprints influence migration patterns, showing cells can switch between confined, oscillatory, and exploratory motion based on footprint deposition and response.

This study identifies an active mechanical mechanism involving PDGFRA+ mesenchymal cells that pattern and fold intestinal villi through myosin II-dependent forces and matrix metalloproteinase-mediated tissue fluidization.

This study develops a model showing that rapid actin filament growth leads to kinetic trapping of bent filaments, influenced by subunit availability and crosslinking.

This study shows cofilin and CAP promote depolymerization of ADP-Pi actin filaments, though at lower rates than ADP filaments, suggesting new pathways for actin filament disassembly.

The paper shows that soft extracellular matrix induces S-phase quiescence in progenitor cells via endoplasmic reticulum stress, aligning with molecular traits of pulmonary basal cells.

The paper identifies ACTN4-dependent ruffle-edge lamellipodia as a novel mode of cell migration using live-cell imaging and CLEM, showing their role in cancer cell invasion.

The paper shows that mechanical compressive forces enhance fusion in trophoblast cell cultures, suggesting a role for biomechanics in placental development.

The paper introduces SP2G, a method to identify invasive sub-populations in glioblastoma cells by analyzing their motility on gridded micropatterns and linking it to molecular markers.

The paper uses a physics-based model to show how polarized ion carriers and environmental gradients affect intracellular pH, electric potential, and cell movement.

The paper develops a Bayesian optimization framework to reverse-engineer morphogenesis by calibrating physics-based models to match experimental imaging data of Drosophila wing imaginal discs.

The paper shows that actin-binding proteins forming liquid-like condensates can polymerize and bundle actin filaments, expanding the known set of proteins capable of this function.

This study shows that monocytes use an amoeboid migration mode in confining channels, driven by cofilin-1-mediated actin remodeling and myosin contractility at the cell rear.