Traumatic Brain Injury Research

White Matter Disruption in Pediatric Traumatic Brain Injury: Results from ENIGMA Pediatric msTBI

This study analyzes diffusion MRI data from 507 children with and without traumatic brain injury to characterize white matter disruption across injury stages and its association with neurobehavioral outcomes.

Increased severity of closed head injury or repetitive subconcussive head impacts enhances post-traumatic headache-like behaviors in a rat model.

This study shows that severe head injury or repetitive subconcussive impacts in rats lead to prolonged headache-like behaviors, which can be reduced by anti-CGRP treatment.

Integrity of anterior corpus callosum is well related to language impairment after traumatic brain injury

This study examines the relationship between corpus callosum integrity and language impairment after traumatic brain injury using diffusion tensor imaging.

Multifactorial and closed head impact traumatic brain injuries cause distinct tactile hypersensitivity profiles

This study characterizes two models of post-traumatic headache, showing distinct tactile hypersensitivity profiles and highlighting the role of CGRP in persistent hypersensitivity.

Implementing an algorithm for controlling for female MC phase for clinical neuroscience

The paper develops an algorithm to characterize menstrual cycle phase and hormone levels in women using and not using hormonal contraceptives, applied to study mTBI outcomes in female athletes.

Myelin water fraction decrease in mild traumatic brain injury

This study uses myelin water imaging to show a decrease in myelin water fraction in chronic mild traumatic brain injury compared to healthy controls.

Optimizing the Accuracy of Cortical Volumetric Analysis in Traumatic Brain Injury

This study introduces a lesion correction method for cortical volumetric analysis in TBI patients, improving accuracy and enabling inclusion of lesioned brains in network-based analyses.

Tracking attention in a visual active paradigm for the diagnosis of disorders of consciousness

This study evaluates an attention-based EEG paradigm to detect volitional brain responses in disorders of consciousness, finding responses in some patients without behavioral responses.

Disrupted information flow in resting-state in adolescents with sports related concussion

This study compares information flow patterns in healthy and concussed adolescents using EEG data, finding altered flow patterns and distribution in the concussed group.

Reading eye movements in traumatic brain injury

This study measures reading eye movements in traumatic brain injury patients using ReadAlyzer and finds significant differences compared to controls.

Default mode network anatomy and function is linked to pediatric concussion recovery

The paper links anatomical and functional brain features of the default mode network to pediatric concussion recovery and shows they predict persistent symptoms.

Dissecting the coma spectrum using Bayesian classification

This paper presents a Bayesian classification method to disambiguate coma subgroups using electrophysiological responses, finding no evidence of subgroups in a small patient sample.

Long-term cognitive impairment without diffuse axonal injury following repetitive mild traumatic brain injury in rats

This study shows that repetitive mild traumatic brain injury in rats causes long-term cognitive impairment without diffuse axonal injury, and identifies a lack of common biomarkers for this condition.

Longitudinal increases in structural connectome segregation and functional connectome integration are associated with better recovery after mild TBI

The paper examines how changes in structural and functional connectomes relate to cognitive recovery after mild TBI, finding that increased network diffusion model propagation time, structural segregation, and functional integration correlate with better recovery.

The thalamic basis of outcome and cognitive impairment in traumatic brain injury

The paper investigates how subcortical brain damage, particularly in the thalamus, relates to functional outcome and cognitive impairment six months after traumatic brain injury.

Repetitive subconcussive head impacts and changes in sensory processing for balance control

This study investigates whether repetitive subconcussive head impacts affect sensory processing for balance control during standing and walking, finding no acute impairments.

Predictive analysis of patient recovery from cardiac-respiratory arrest

The paper predicts patient recovery from cardiac-respiratory arrest using EEG-based features from auditory responses to determine consciousness outcomes.

Automated Pupillometry to Detect Command Following in Neurological Patients: A Proof-of-Concept Study

This study tests automated pupillometry with mental arithmetic to detect command following in neurological patients, finding it effective in healthy volunteers and some patients.

Decreased grey matter volume in mTBI patients with post-traumatic headache compared to headache-free mTBI patients and healthy controls: a longitudinal MRI study

This study finds that mTBI patients with post-traumatic headache have reduced grey matter volume in specific brain regions compared to those without headache and healthy controls.

Relating brain connectivity with persistent symptoms in pediatric concussion

This study links brain connectivity patterns with persistent symptoms in children after mild traumatic brain injury using resting-state fMRI and behavioral assessments.

Repetitive mild concussion in subjects with a vulnerable cholinergic system: lasting cholinergic-attentional impairments in CHT+/- mice.

This study shows that mice with reduced cholinergic capacity experience severe, lasting attention impairments after repeated mild concussions, suggesting similar risks in humans with vulnerable cholinergic systems.

\"DoC-feeling\": a new behavioural tool to help diagnose the Minimally Conscious State.

The paper introduces a new behavioral tool called 'DoC-feeling' that uses aggregated nursing staff assessments to detect the Minimally Conscious State with high accuracy.

Sleep-like bistability, loss of causality and complexity in the brain of Unresponsive Wakefulness Syndrome patients

This study links pathological bistability in UWS patients to reduced brain complexity using TMS/EEG and PCI measurements.

A Russian validation study of the Coma Recovery Scale-Revised (CRS-R)

This study validates a Russian adaptation of the Coma Recovery Scale-Revised (CRS-R) in patients with chronic disorders of consciousness, showing good reliability, validity, and sensitivity for assessing recovery.

In vivo cerebral microdialysis validation of the acute central glutamate response in a translational rat model of concussion combining force and rotation

This study validates the Wayne State weight-drop model of concussion in rats using cerebral microdialysis, showing a 3-fold increase in hippocampal glutamate levels within 10 minutes of injury.

Single Cell Molecular Alterations Reveal Pathogenesis and Targets of Concussive Brain Injury

This study uses single-cell sequencing to identify hippocampal cell types and genes vulnerable to concussive TBI, revealing pathogenic mechanisms and therapeutic targets.

A model of repetitive mild brain injury without symptoms – risk for Parkinson’s disease with aging?

This study investigates whether repetitive mild brain injury in rats leads to long-term brain changes associated with Parkinson's disease risk.

Oscillatory Default Mode Network Coupling In Concussion

This study examines how concussion affects functional brain networks using MEG, finding increased connectivity in the default mode and motor networks associated with symptoms.

The relationship between brain atrophy and cognitive-behavioral symptoms in retired Canadian football players with multiple concussions

This study examines the link between multiple concussions and brain atrophy in retired Canadian football players, finding greater hippocampal atrophy and poorer verbal memory performance compared to controls.

Common neural responses to narrative speech indisorders of consciousness

The paper uses inter-subject correlations of EEG responses to narrative speech to assess auditory attention in disorders of consciousness, finding lower correlations in patients compared to controls.