Traumatic Brain Injury Research

Repetitive mild traumatic brain injury impairs resting state fMRI connectivity and alters protein profile signaling networks

This study investigates how repetitive mild traumatic brain injury (rmTBI) affects brain functional connectivity and protein profiles in mice, revealing altered connectivity and inflammatory responses.

Localized, time-dependent responses of rat cranial bone to repeated mild traumatic brain injuries

This study shows that repeated mild traumatic brain injuries (rmTBI) cause time- and location-dependent changes in cranial bone structure in rats, specifically increasing bone thickness and reducing marrow cavity volume in the interparietal bone.

Involvement of Lateral Habenula Dysfunction in Repetitive Mild Traumatic Brain Injury-Induced Motivational Deficits

This study shows that repetitive mTBI causes LHb neuronal dysfunction, leading to motivational deficits, and that inhibiting LHb activity can reverse these deficits.

Apolipoprotein E genotype modulates longitudinal atrophy at the temporal lobe after mild traumatic brain injury

The paper examines how APOE ε4 genotype affects longitudinal temporal lobe atrophy in patients with mild traumatic brain injury compared to healthy controls.

Inflammation and neuronal gene expression changes differ in early vs late chronic traumatic encephalopathy brain

The paper compares gene expression changes in early and late stages of chronic traumatic encephalopathy (CTE) and identifies factors influencing disease expression.

Identifying Neural Correlates of Balance Deficits in Traumatic Brain Injury Using Partial Least Squares Correlation (PLSC) Analysis

The paper uses PLSC analysis to identify neural correlates of balance deficits in TBI by stratifying patients based on functional outcomes and analyzing brain connectivity.

Numerical Simulation of Concussive-generated Cortical Spreading Depolarization to Optimize DC-EEG Electrode Spacing for Non-invasive Visual Detection

The paper simulates cortical spreading depolarization (SD) to determine optimal EEG electrode spacing for non-invasive detection of SD in concussion.

Wide-field Calcium Imaging Reveals Widespread Changes in Cortical Connectivity Following Repetitive, Mild Traumatic Brain Injury in the Mouse

This study uses calcium imaging to show that repetitive mild traumatic brain injury in mice causes long-term changes in cortical functional connectivity without affecting cognitive or motor function.

Thalamo-Prefrontal Connectivity Correlates with Early Command-Following After Severe Traumatic Brain injury

This study finds that thalamo-prefrontal connectivity, assessed via DTI, predicts early command-following after severe TBI with 72% accuracy.

Repeated blast mild traumatic brain injury and oxycodone self-administration produce interactive effects on neuroimaging outcomes

This study investigates how repeated blast TBI and oxycodone self-administration interact to affect neuroimaging outcomes and drug seeking behavior in rats.

Structural brain connectivity predicts acute pain after mild traumatic brain injury

This study uses machine learning to show that white matter connectivity in specific brain networks predicts acute pain after mild traumatic brain injury.

Towards Understanding Comprehensive Morphometric Changes and Its Correlation with Cognition and Exposure to Fighting in Active Professional Boxers

This study compares neuroanatomical differences between impaired and nonimpaired active professional boxers using morphometric and machine-learning analyses.

Temporal Lobe Activation Predicts Episodic Memory Following Traumatic Brain Injury

This study finds that reduced temporal lobe activation for faces and scenes predicts episodic memory deficits after traumatic brain injury, despite normal behavioral performance.

Development of a new militarily-relevant whole-body low-intensity blast model for mild and subconcussive traumatic brain injury: Examination of acute neurological and multi-organ pathological outcomes

This paper develops a new mouse model for blast-induced traumatic brain injury (BINT) and examines acute neurological and multi-organ outcomes.

Long-term effects of moderate concussive brain injury during adolescence on synaptic and tonic GABA currents in dentate projection neurons.

This study examines how moderate concussive brain injury in adolescent rats affects GABA currents in dentate projection neurons over time, showing changes in granule cells but not semilunar granule cells.

Cerebrovascular responses to O2-CO2 exchange ratio under brief breath-hold challenge in patients with chronic mild traumatic brain injury

This study examines cerebrovascular responses to breath-hold challenges in patients with chronic mild traumatic brain injury using respiratory gas exchange metrics and fMRI.

Recurrent Neural Network-based Acute Concussion Classifier using Raw Resting State EEG Data

This paper introduces an LSTM-based classifier that accurately distinguishes acute concussions from healthy states using raw resting state EEG data from adolescent athletes.

Characterization of cognitive-motor function in women who have experienced intimate partner violence-related brain injury

This study examines cognitive-motor function in women with IPV-related brain injury using the OHA task, finding BI load and comorbidities significantly affect performance.

Altered oligodendroglia and astroglia in chronic traumatic encephalopathy

This study identifies molecular and cellular changes in oligodendrocytes and astrocytes in CTE using single-nucleus RNA sequencing and histological analysis.

Repetitive Mild Head Trauma Induces Activity-Mediated Lifelong Brain Deficits in a Novel Drosophila Model

This study shows that repetitive mild head trauma in Drosophila causes long-term brain deficits, worsened in females, and links increased neuronal activity to chronic degeneration.

A Multiscale Model of Traumatic Brain Injury Suggests Possible Mechanisms of Post-Traumatic Psychosis

This paper proposes a multiscale model of traumatic brain injury to explore mechanisms of post-traumatic psychosis by linking molecular pathology to brain connectivity and function.

Relationships between biomechanical parameters, neurological recovery, and neuropathology following concussion in swine

This study examines the relationship between biomechanical parameters, neurological recovery, and neuropathology in swine following concussion, finding correlations between injury kinematics and recovery outcomes.

Aberrant modulation of brain activity underlies impaired working memory following traumatic brain injury

This study investigates how traumatic brain injury affects working memory by analyzing neural activity patterns during different cognitive load conditions.

Repetitive mild traumatic brain injury causes synergistic effects on mortality

This study investigates the mortality pattern caused by repetitive mild traumatic brain injury in fruit flies using a modified high-impact trauma method, finding synergistic effects after a critical number of injuries.

Association between proteomic blood biomarkers and DTI/NODDI metrics in adolescent football players

The paper examines the association between diffusion MRI metrics and blood biomarkers in adolescent athletes, finding links between Tau levels and microstructural changes in the corpus callosum.

Repetitive blast promotes chronic aversion to neutral cues encountered in the peri-blast environment

This study shows that repetitive blast exposure in mice leads to chronic aversive responses to environmental cues, unlike single exposures, highlighting the complex effects of repeated trauma.

A comparison of cognitive-motor integration performance and resting state functional brain network connectivity in female athletes suggests intact motor network and visuomotor skill in those with a concussion history

This study compares cognitive-motor integration performance and resting state functional connectivity in female athletes with and without concussion history, finding no performance differences or correlations between connectivity and behavior.

Neural markers of vulnerability to anxiety outcomes following traumatic brain injury

The paper identifies neural markers of anxiety vulnerability after traumatic brain injury by analyzing molecular profiles in vulnerable mice.

Graph-theoretical Analysis of EEG Functional Connectivity during Balance Perturbation in Traumatic Brain Injury: A Pilot Study.

This study uses graph-theoretical analysis of EEG functional connectivity to examine balance impairment in TBI patients compared to healthy controls, finding altered network segregation and structural connectivity.

EEG power spectra and subcortical pathology in chronic disorders of consciousness

The paper examines the relationship between EEG power spectra, subcortical damage, and consciousness disorders, showing how combining EEG, clinical, and MRI data can improve diagnosis.