Memory and Neural Mechanisms

Hippocampus-evoked polysynaptic responses in the medial prefrontal cortex are attenuated in aged rats.

This study shows that aging in rats reduces polysynaptic responses in the medial prefrontal cortex but preserves direct synaptic transmission from the hippocampus.

Physical restraint induces conditioned place aversion and region-specific c-Fos activation in mice

This study shows that physical restraint in mice leads to conditioned place aversion and region-specific c-Fos activation in brain areas related to aversion and context.

Structured and flexible representations in medial-frontal cortex support goal-directed navigation

This study identifies two distinct neural representations in mouse medial frontal cortex during flexible navigation, showing how they encode position and goal distance to guide behavior.

Associative emotional memory encoding: Insights from network stability analysis of an fMRI-driven bilinear dynamics

The paper analyzes neuronal dynamics during emotional memory encoding using fMRI data, finding that emotional conditions enhance memory through increased hippocampus-amygdala coupling and network connectivity.

Anterior hippocampal integration tracks the developmental emergence of flexible navigation through changing environments

This study shows that anterior hippocampal temporal autocorrelation increases with age and supports the development of flexible navigation through changing environments.

Boundary Vector Cells Encode a Future-Biased Spectrum of Positions in the Rat

The paper analyzes boundary vector cells in the rat subiculum to show they encode future states with a multi-scale temporal integration of behavioral information.

Hippocampal CA2 modulates trace fear conditioning through circuit-specific control of CA1

This study shows that the dorsal CA2 region modulates trace fear conditioning by differentially affecting CA1 through projection-specific signaling.

Predictive learning induces Bayesian cognitive maps in the hippocampus

This study shows that predictive learning in recurrent neural networks generates Bayesian cognitive maps similar to hippocampal place cell activity, outperforming autoencoders.

Flexible route planning and rapid structure learning by mice in complex environments

The paper develops a behavioural assay to study flexible navigation in mice, showing they learn maze structures quickly and navigate efficiently.

Conjunctive coding of letter pairs emerges in segregated human medial temporal lobe neurons during working memory

The paper shows that human medial temporal lobe neurons encode letter pairs through a segregated population during working memory, independent of single letter encoding.

Hippocampal consummatory reward ensembles dynamically engage theta-SWR states during spatial working memory

The paper identifies reward-ensemble neurons in the hippocampus that show state-dependent coordination with theta-SWR dynamics during spatial working memory.

A synaptic mechanism for encoding the learned value of action-derived safety

The paper identifies a thalamostriatal circuit mechanism by which internally constructed outcomes, like safety, acquire motivational value through synaptic plasticity in mice.

BIOPHYSICAL MECHANISMS UNDERLYING THE GENERATION AND MAINTENANCE OF RULE-LEARNING ENGRAM

The paper shows that rule-learning in rodents occurs abruptly through a discrete moment involving enhanced intrinsic excitability, synaptic changes, and a decline in IEG-expressing neurons.

The representational geometry of emotional states in basolateral amygdala

The paper investigates how the basolateral amygdala encodes emotional states through representational geometry, finding that valence and motor responses are encoded in orthogonal directions enabling specialized readouts.

Distance Mapping and Variable-Specific Geometry of Goal-Relevant Frames in the Retrosplenial Cortex

This paper investigates how retrosplenial cortex encodes goal-relevant spatial information during navigation and foraging in rats, finding task-dependent representations of distance and boundary signals.

Synaptic histamine shapes the neurocomputational dynamics of human learning

This study shows how increased synaptic histamine affects hippocampal dynamics and learning by using a causal probe and analyzing neurocomputational strategies.

A model of schema learning based on biological dimensionality reduction during sleep

This paper proposes a theoretical model of schema learning through low-dimensional neural representations formed during sleep-driven dimensionality reduction.

Distinct roles of hippocampus and neocortex in symbolic compositional generalization

The paper investigates how the hippocampus and neocortex contribute to symbolic compositional generalization by analyzing BOLD data during a spatial inference task.

Context Shapes Fear: Habituation of Innate Defensive Behaviours Depends on Environmental Context

This study shows that habituation of innate defensive behaviors in mice depends on environmental context, with context-specific habituation being reversible.

A learning-evoked slow-oscillatory architecture paces population activity for offline reactivation across the human medial temporal lobe

The paper identifies a slow-oscillatory architecture in the human medial temporal lobe that coordinates population activity during learning and facilitates offline reactivation and recall.

Infraslow histaminergic dynamics govern priming states to gate moment-to-moment memory accessibility

The paper shows that infraslow histaminergic activity in mice modulates memory expression by priming BLA circuits, influencing moment-to-moment memory accessibility.

The impact of contingency awareness on the neurocircuitry underlying pain-related fear and safety learning

The paper investigates how contingency awareness affects neural circuits involved in visceral pain-related fear and safety learning using fMRI data from healthy individuals.

The hippocampus as a small-world cognitive map

The paper uses a geometry-aware autoencoder to analyze hippocampal activity in mice, revealing a small-world network structure that enables both local fidelity and global searchability in cognitive maps.

Paraventricular thalamus gates hippocampal coding of salient experiences.

This study identifies a thalamic circuit that biases hippocampal coding toward aversive stimuli and influences approach-avoidance behaviors.

Hippocampal and prefrontal contributions to memory-guided navigation depend on task epoch

This study investigates the role of hippocampus and prefrontal cortex in memory-guided navigation by testing their contribution during different task phases in mice.

FASTIMAGES: Validating replay detection methods in human Neuroimaging using a combined MEG and fMRI dataset

The paper introduces FASTIMAGES, a benchmark dataset combining MEG and fMRI to evaluate replay detection methods in humans, showing method-specific strengths and cross-modality challenges.

Naturalistic behavior and self-generated neural activity predictive of self-correction.

The paper develops a task for rats to study self-correction and finds distinct hippocampal representations during this process.

An image-computable characterization of the non-conditioned linkage of visual drive and valence in the primate amygdala

The paper shows that primate amygdala neurons have visual selectivity linked to valence without conditioning, using image-computable models to predict this relationship.

Evaluating Place Cell Detection Methods in Ratsand Humans: Implications for Cross-Species Spatial Coding

This study compares place cell detection methods in rats and humans, showing methodological differences affect identified place cell properties and cross-species comparisons.

Conserved inhibitory motifs yield distinct hippocampal functions through regional circuit embedding

The paper shows that OLM2 interneurons in different hippocampal regions have distinct functions based on their connectivity, influencing behavior and emotional responses differently.