Memory and Neural Mechanisms

The genetic signature of memory encoding along the human hippocampal axis

The paper links hippocampal oscillatory activity during memory encoding to distinct molecular programs in anterior and posterior hippocampus using single-nucleus RNA sequencing and spatial transcriptomics.

Preserved geometry during representational drift enables stable perception and memory

The paper provides a mathematical framework explaining when stable decoding of drifting neural representations is possible, showing that preserved geometry and large neuronal populations enable this.

Arousal state modulates human hippocampal ripples

This study shows that human hippocampal ripples are modulated by arousal states, occurring more frequently during low arousal periods like sleep and certain wake states.

Old mice fail to integrate a memory update into an existing hippocampal engram.

This study shows that old mice have difficulty updating existing memories in the hippocampus, but re-engaging the original memory engram can improve this ability.

The precision of hippocampal representations predicts incremental value-learning across the adult lifespan

This study shows that hippocampal representation precision predicts value-learning accuracy across age groups, with reduced hippocampal-mPFC connectivity linked to poorer performance in older adults.

Fine mapping of PTSD GWAS reveals a role for amygdala Foxp2 in regulation of fear and threat responses

This study fine-maps PTSD GWAS data with amygdala eQTLs and shows FOXP2 expression is linked to increased PTSD risk, with functional validation in mice and humans.

Hippocampo-neocortical interaction as compressive retrieval-augmented generation

The paper presents a computational model of hippocampo-neocortical interaction that simulates memory encoding, retrieval, and problem solving through compressive retrieval-augmented generation.

What group averages conceal: functional heterogeneity in human eyeblink habituation

The paper analyzes human eyeblink habituation data to show that group-averaged habituation curves can misrepresent individual variability in curve shapes.

An abstract relational map emerges in the human medial prefrontal cortex with consolidation

The paper investigates the emergence of abstract relational representations in the human medial prefrontal cortex over time using fMRI and graph-learning paradigms.

Inside insight: decoding how insight emerges from competing world models

This paper introduces a machine-learning framework to estimate latent world-model dynamics from behavioral data and applies it to analyze insight-like shifts in mouse behavior.

Dynamic cognitive representations in the dorsal pallium of adult zebrafish

The paper investigates spatial representations in the dorsal pallium of adult zebrafish, showing neurons encode environmental space with landmark associations and internal predictive models.

Strain- and age-dependent divergence in mouse appetitive spatial learning and decision strategies

This study investigates how mouse strain and age influence spatial learning and decision strategies in a T-maze task, revealing strain- and age-dependent differences in performance and decision policies.

Paraventricular Thalamus Hyperactivity Mediates Stress-Induced Sensitization of Unlearned Fear but Not Stress-Enhanced Fear Learning (SEFL)

This study identifies paraventricular thalamus hyperactivity as a mechanism for stress-induced sensitization of unlearned fear, distinct from stress-enhanced fear learning.

THE SUBTHALAMIC NUCLEUS IS INVOLVED IN SOCIAL MEMORY IN MALE RATS

This study investigates the role of the subthalamic nucleus in social memory in male rats using pharmacological, optogenetic, and electrical stimulation methods, finding that STN manipulations selectively impair social discrimination memory.

The parafascicular thalamus steers attention to facilitate learning

The paper shows that parafascicular thalamus (PF) neurons encode cue-directed behavior and associative learning, with their activity modulated by reward and extinction.

Infantile engram modulates memory formation during adulthood

The paper shows that infantile engram cells in the infralimbic cortex influence adult memory formation through relearning, despite infantile amnesia.

TIME BETWEEN LEARNING EVENTS SHAPES FUNCTIONAL CONNECTIVITY IN SPATIAL MEMORY, A BRAIN-WIDE ANALYSIS

The paper investigates how spaced versus massed training affects brain network organization in spatial memory, finding that spaced training promotes more integrated cortical-thalamic networks.

Single-cell chromatin tracing reveals multimodal molecular programs during memory formation

The paper develops ChromTRAP to identify recently activated neuronal ensembles and reveals brain-region- and cell-type-specific regulatory programs during learning.

DeltaQ: Value-Guided Hebbian Learning in Spiking Neuronal Networks for Multi-Goal Navigation

The paper introduces a spiking neuronal network model that uses spatial representations, value-guided plasticity, and contextual modulation to enable flexible navigation under sparse reward conditions.

Distributed neuronal ensembles support episodic-like memory retrieval

The paper identifies a distributed brain network involved in episodic-like memory retrieval in mice by analyzing c-Fos activation and chemogenetic manipulations.

Intrinsic persistent firing in CA1 encodes elapsed time across behaviorally relevant scales

The paper shows that single neurons in rat hippocampal CA1 slices can encode elapsed time over multi-second intervals through intrinsic mechanisms.

CA3 Transiently Modulates Spatial Representation in CA1

This study shows that CA3 input transiently modulates spatial coding in CA1 by inducing new place cells and shifting existing place fields without altering tuning or precision.

Transformations of the spatial activity manifold convey aversive information in CA3

The paper shows that CA3 axons maintain a stable spatial coding manifold that encodes aversive information without disrupting spatial representation.

Time, but not reward, shapes replay-based episodic prioritization

The paper shows that time, not reward, influences which experiences are prioritized for replay during learning and sleep, suggesting a temporal decay mechanism for memory consolidation.

Interplay of sleep neural oscillations enhances coordinated memory reactivation between cortex and hippocampus

The paper shows that sleep oscillations coordinate specific memory reactivation between the hippocampus and cortex, enhancing memory consolidation.

Fleeing is Believing: Adaptive behavior under social threat as an inference process

This paper models social defeat in mice as a POMDP to understand how adverse social experiences reshape decision-making and predict behavioral outcomes.

Basolateral amygdala dopamine transmits emotional salience

This study investigates how BLA dopamine signaling encodes emotional salience during associative learning, showing it reflects relative stimulus importance rather than associative strength or reward value.

A Two-Dimensional Grid-Cell Code for Three-Dimensional Navigation in Freely Flying Bats

The paper shows that grid cells in bats use a two-dimensional toroidal code to navigate three-dimensional space by aligning with two-dimensional planes of motion.

GABAergic projection from the subiculum to the medial entorhinal cortex in mice and rats

The paper identifies an inhibitory GABAergic projection from the subiculum to the medial entorhinal cortex in mice and rats, showing species-specific laminar organization.

Dissecting the Role of the Lateral Entorhinal Cortex in Memory Interference

This paper shows that lateral entorhinal cortex inhibition reduces latent inhibition by increasing fear responses to pre-exposed stimuli, suggesting the LEC supports memory interference during retrieval.