Memory and Neural Mechanisms

Hippocampal astrocytes contribute to encoding context-specific aversive stimuli to regulate fear-related behavior

This study shows that hippocampal astrocytes encode context-specific aversive stimuli to regulate fear-related behavior through Ca2+ activity preceding freezing responses.

Hippocampus-reuniens beta coupling supports goal-directed spatial navigation

This paper investigates HC-RE-PFC network dynamics during spatial navigation in rats, finding that beta-band coupling between hippocampus and reuniens emerges during goal-directed learning and correlates with navigational efficiency.

A simple model of the co-emergence of grid and place fields

This paper introduces a unified recurrent network model that co-emerges grid and place cells without supervision or pre-existing spatial-cell representations, reproducing experimental observations.

Direct electrical stimulation of the human amygdala enhances recognition memory for objects but not scenes

This study uses direct electrical stimulation of the human amygdala to show it enhances object memory but not scene memory, suggesting specificity in memory prioritization.

Semantic map learning and externalization in an embodied neural agent: A comparison to human behavioral and neural data

The paper develops a spiking semantic SLAM algorithm for an embodied neural agent and compares its behavior to human spatial memory and neural data in a virtual reality task.

A cognitive map of subjective value space for human risky choice

This study uses fMRI to show that a two-dimensional subjective value space is represented in the cognitive mapping system during risky decision-making.

Visuospatial coding by theta oscillations in human hippocampus

The paper investigates visuospatial coding in the human hippocampus using intracranial EEG during a retinotopic mapping task, finding that slow theta oscillations scale with visual stimulus size and show contralateral bias.

Distinct developmental trajectories of externally- and internally-generated hippocampal sequences and assemblies

The paper investigates the developmental emergence of internal and external hippocampal representations in mice, finding that internal sequences appear at postnatal day 24, following cue-based representations.

Reward-tethered place cells support flexible magnitude coding and remapping in the hippocampus

The paper shows that reward-tethered place cells in the hippocampus adjust their activity when reward magnitude changes, enabling flexible coding and remapping while preserving spatial maps.

Sex-specific plasticity mechanisms mediating fear extinction

The paper shows that male and female mice use different synaptic plasticity mechanisms for fear extinction, with males showing structural remodeling and GRIN2B dependence, while females do not.

Reduced MOV10 reveals novel functional cortical connections in an increased fear response

This study shows that MOV10 loss in mice leads to enhanced fear learning through altered cortical connectivity and increased GABRA2 expression, suggesting new mechanisms for fear memory and potential therapeutic targets.

Projections from subfornical organ to infralimbic cortex modulate carbon dioxide associated fear

This study identifies a neural circuit involving the subfornical organ and infralimbic cortex that modulates fear responses to carbon dioxide, linking interoceptive signals to fear behavior.

Vision shapes neural maps of space through an ancient midbrain pathway

The paper shows that visual signals reach the hippocampus through a conserved midbrain pathway, enabling spatial maps even after visual cortex ablation.

Fixation-locked hippocampal activity reflects semantic content and temporal order of visual exploration during scene encoding

The paper shows that hippocampal activity during scene encoding reflects the semantic content and temporal order of visual fixations, with first fixations on people being most significant for memory.

BOLD signals of learning dynamics across and within trials beyond the classical fear and extinction network

This study examines temporal dynamics of neural responses during fear conditioning and extinction by analyzing three 2s segments within CS presentation, revealing distinct activation patterns across and within trials.

Hippocampal ripples evoke a stereotyped cortical response followed by spindle-mediated network synchronization.

The paper shows hippocampal ripples trigger a two-step cortical response during sleep, followed by spindle-mediated network synchronization, and demonstrates this can be detected noninvasively with scalp EEG.

Long-term memory reorganization of navigational episodes

This study shows that navigational memory continues to transform over decades, combining schematic information with spatial representations that decay at different rates.

Pyramidal-cell-specific hemispheric asymmetry shapes dorsoventral CA1 dynamics during rest and exploratory behavior

The paper shows that dorsal CA1 pyramidal neurons exhibit left-hemisphere bias and cell-type-specific asymmetry, shaping activity and behavior during rest and exploration.

Cortical Serotonin Type 2A Receptor Activation Shields Episodic-like Memories from Retroactive Interference in Rodents

This study shows that activating serotonin 2A receptors in the medial prefrontal cortex prevents retroactive interference in rodents by enhancing memory access rather than erasing memory traces.

Mapping mouse hippocampal output circuits using direction-selective anterograde transsynaptic transduction

The paper develops a direction-selective anterograde transsynaptic transduction method to map hippocampal output circuits in mice, focusing on projection targets like the amygdala.

Subregional activity in the dentate gyrus is amplified during elevated cognitive demands

This study shows that increased cognitive demand in mice enhances spatial activity in the suprapyramidal blade of the dentate gyrus, with specific roles for mature and adult-born granule cells.

Spatial remapping in the subicular complex and entorhinal cortex follows low-dimensional geometric principles

The paper shows that spatial remapping in the hippocampal formation follows low-dimensional geometric transformations across environments.

Subspace communication in the hippocampal-retrosplenial axis

The paper identifies communication subspaces in the hippocampal-retrosplenial circuit using partial canonical correlation analysis, showing how these subspaces reconfigure to support flexible encoding of experiences.

A Frontal-Sensory Cortex Circuit Encoding Context-Dependent Stimulus Statistics

The paper investigates how mice encode context-dependent stimulus probabilities in frontal-sensory circuits, showing distinct neuronal activity patterns in piriform and orbitofrontal cortices during learning.

Trajectories of hippocampal subregion development in the first years of life and their association with school-aged episodic memory outcomes

This study examines hippocampal subregion development in early life and links growth patterns to school-aged episodic memory performance.

The role of the ventral midline thalamus in the retrieval of precise temporal memories

This study investigates the role of the ventral midline thalamus in retrieving precise temporal memories using a fixed-interval timing task in rats, showing that muscimol infusions impair timing precision.

MicroRNA-29 acutely regulates Memory Stability, Expression of Synaptic Genes, and DNA Methylation in the Mouse Adult Hippocampus

This study shows that miR-29 regulates memory stability, synaptic gene expression, and DNA methylation in adult mouse hippocampus by modulating Dnmt3a levels.

Shared early impairments of medial entorhinal cortex function across distinct Alzheimer's disease etiologies

This study identifies shared early impairments in spatial context representation in the medial entorhinal cortex across two distinct Alzheimer's disease mouse models.

Hippocampal theta frequency as a readout of path-integration recalibration

The paper shows that theta frequency reflects internal path-integration gain errors during navigation, providing a method to estimate hidden cognitive variables through physiological oscillations.

Hippocampus single-nucleus transcriptomics reveals coordinated regulation of social and spatial representation development by perinatal SERT expression in CA3 pyramidal neurons

This study uses single-nucleus transcriptomics to show that perinatal SERT expression in CA3 pyramidal neurons affects gene expression in specific brain regions, with implications for social and spatial circuit development and autism-related genes.