Memory and Neural Mechanisms

A Conserved Mammalian Hippocampal Navigation Motif Reconfigured for Primate Vision

This study shows that marmosets, like rodents, alternate between locomotion and pauses during navigation, with SWR rates increasing during pauses and memory-guided navigation.

A molecularly defined brain circuit module for regulating the panic-like defensive state

The paper identifies Cbln2-expressing neurons in the posterior hypothalamic nucleus as essential for inducing panic-like defensive state in mice.

RAINSTORM: Automated Behavioral Analysis for Mice Exploratory Behavior Using Artificial Neural Networks.

RAINSTORM automates behavioral analysis of mice exploratory behavior using AI, improving reliability and efficiency by reducing subjectivity in scoring.

An intracranial dissection of human escape circuits

This study uses iEEG to identify distinct brain circuits involved in human escape responses, showing the reactive fear circuit dominates during rapid attacks while the cognitive fear circuit processes threat information.

Modulation of aggression by social novelty recognition memory in the hippocampal CA2 region

This study investigates the role of the dorsal CA2 hippocampal region in social aggression and novelty recognition memory, finding that dCA2 promotes aggression towards novel conspecifics through its ability to distinguish novelty.

Large sharp-wave ripples promote hippocampo-cortical memory reactivation and consolidation

The paper identifies large sharp-wave ripples (SWRs) that enhance memory reactivation and consolidation in mice by improving hippocampal and prefrontal cortex coordination during sleep.

A selective top-down pathway from anterior cingulate cortex embeds a representation of saliency in hippocampus

This study identifies a top-down pathway from the anterior cingulate cortex to the retrosplenial cortex that encodes reward-context associations and shapes hippocampal saliency maps.

Event structure sculpts neural population dynamics in the lateral entorhinal cortex

This study shows that neural activity in the lateral entorhinal cortex of rats organizes events into continuous, directional flows with discrete boundaries, enabling multiplexing across timescales.

Chemogenetic inhibition of amygdala to ventrolateral prefrontal cortex communication selectively impacts contingent learning

This study investigates the role of amygdala to ventrolateral prefrontal cortex (vlPFC) projections in contingent learning by inhibiting these connections in macaques and observing effects on reward signaling and choice memory.

Task engagement differentially drives hippocampal and neocortical neural codes

The paper shows that visual cortex maintains sensory discrimination regardless of behavior, while the hippocampal dentate gyrus requires active navigation for effective discrimination.

REACTIVATION PROTECTS MOTOR MEMORIES FROM INTERFERENCE BY COMPETING LEARNING

This study tests whether reactivating a motor memory affects its susceptibility to interference from competing learning, finding that reactivation reduces interference when the competing memory cannot stabilize.

Cortical dissociation of spatial reference frames during place navigation

The paper investigates how spatial reference frames differ between the postrhinal cortex (POR) and medial entorhinal cortex (MEC) during place navigation in rats, finding that POR neurons adapt to visual landmarks while MEC neurons maintain a stable allocentric representation.

Deceptive safety? The impact of costly pain avoidance on the modulation and extinction of visceral pain-related fear

This study investigates how costly avoidance affects the modulation and extinction of visceral pain-related fear, finding that avoidance maintains fear and may hinder extinction.

Specific anterior-posterior brain-wide input patterns support specialized visuospatial processing in the mouse retrosplenial cortex

The paper identifies distinct anterior-posterior subregions in the mouse retrosplenial cortex specialized for different visuospatial processing tasks.

Spatially and non-spatially tuned hippocampal neurons are linear perceptual and nonlinear memory encoders

This study shows that hippocampal neurons use both linear and nonlinear computations to encode perceptual and memory information, challenging the traditional spatial vs. non-spatial dichotomy.

Charting the single cell transcriptional landscape governing visual imprinting.

The paper identifies transcriptional changes in the avian brain during visual imprinting using single-nucleus RNA sequencing, revealing cell clusters and lncRNAs linked to memory formation.

Impact of symmetry in local learning rules on predictive neural representations and generalization in spatial navigation

This paper investigates how symmetric learning rules affect predictive neural representations and generalization in spatial navigation using a neural network model of hippocampal subfields.

ABBA, a novel tool for whole-brain mapping, reveals brain-wide differences in immediate early genes induction following learning

ABBA and BraiAn tools enable whole-brain mapping of immediate early genes, revealing distinct expression patterns across brain regions and behavioral conditions.

Safety processing shifts from hippocampal to network engagement across adolescence

This study examines how adolescent brains process threat and safety cues, finding a shift from hippocampus-dependent to hippocampus-vmPFC network-dependent safety discrimination as adolescents age.

Reactivation of threat conditioning memory in humans: disentangling the effects on emotional memory and cognitive biases.

This study examines how reactivating threat conditioning memory in humans affects emotional memory and cognitive biases, showing that post-reactivation interventions can reduce physiological and cognitive responses.

Tracking Conditioned Fear in Pair-Housed Mice Using Deep Learning and Real-Time Cue Delivery

This study uses deep learning and real-time cue delivery to analyze fear behaviors in pair-housed mice, finding sex and circadian differences in conditioned freezing responses.

Parallel emergence of perisomatic inhibition and ripples in the developing hippocampal circuit

The paper investigates the parallel development of perisomatic inhibition and ripples in the CA3 and CA1 hippocampal regions, showing they mature together with distinct timing and properties.

HIPPOCAMPAL THETA OSCILLATIONS DURING CONTROLLED SPEED RUNS ON A TREADMILL

This study investigates how movement transitions, speed, and acceleration modulate hippocampal theta oscillations in rats using a controlled treadmill setup, finding that speed, not acceleration, primarily modulates theta frequency.

Dynamic encoding of valence by anterior cingulate cortex in mice

This study shows that ACC neurons in mice dynamically reorganize their responses to fear cues over time, reflecting changes in novelty and negative valence.

Fos labels a distinct excitatory neuron ensemble for memory retrieval

This study shows that Fos labels excitatory neurons specific for memory retrieval, not those activated during memory encoding.

Directed cell-type recruitment during consolidation of a remote memory

The paper identifies prefrontal projection neurons recruited during remote memory consolidation through synaptic activity of learning-activated cells.

Credit Assignment via Behavioral Timescale Synaptic Plasticity: Theoretical Frameworks

This paper introduces a generalized BTSP rule for neural network learning and shows it can perform unsupervised and supervised tasks but faces challenges with network depth.

Cued replay of memory contents in human infants

This paper identifies replay activity in human infants, showing sequential and temporally compressed reactivation of memory contents at 10 months old.

Hippocampal sequences span experience relative to rewards

The paper shows that hippocampal sequences adapt to reward locations, with reward-relative cells spanning task structure and increasing with experience.

Remote activation of place codes by gaze in a highly visual animal

The paper shows that place cells in chickadees activate both when the bird is in a location and when it gazes at it from a distance, linking place coding to gaze through head saccades.