Molecular Sensors and Ion Detection

Coumarin-based blue excitable probe for functional screening of dehalogenase activity

This paper introduces a new fluorescent probe, COU4-Cl, excitable at 405 nm and 488 nm, for detecting dehalogenase activity, and compares it to the existing COU2-Cl probe.

Rhodamine-derived ratiometric fluorescent molecular rotor for mitochondrial viscosity sensing

This paper introduces a new ratiometric fluorescent molecular rotor for mitochondrial viscosity sensing, showing it can quantify inner mitochondrial membrane viscosity and reveal heterogeneity under oxidative stress.

Evaluation of selectively-activatable, caged fluorescent probes as species selective markers for beta-alanine aminopeptidase positive bacterial species

The paper evaluates caged fluorescent probes for detecting beta-alanine aminopeptidase activity in bacterial species, showing selectivity for Pseudomonas aeruginosa, Burkholderia, and some Serratia strains, while being inactive in others.

Near-Infrared Turn-On Fluorogenic Probe for Versatile Detection of Inorganic Polyphosphates

This paper introduces a near-infrared fluorogenic probe for selective detection and imaging of inorganic polyphosphates in various biological contexts.

Rosindol: A fluorogen for the quantitative measurement of reactive oxygen species in living cells

Rosindol is a new fluorogenic probe that accurately measures reactive oxygen species in living cells with linear responses and pH independence.

Single-Molecule Activity Profiling of Glycosidase Proteoforms Using Water-Soluble Fluorogenic Probes

This study develops water-soluble fluorogenic probes for single-molecule glycosidase activity profiling in blood, revealing -mannosidase as a potential biomarker for liver injury.

Targeted fluorescent lipid microparticles for quantitative measurement of phagosomal pH

This paper develops fluorescent lipid microparticles that measure phagosomal pH in real-time by combining pH-responsive dyes with a reference probe.

Cycling Molecular Assemblies (CyMA) for Ultrasensitive Golgi Imaging

The paper introduces BODIPY-CyMA, a probe that uses enzymatic cycles for ultrasensitive Golgi imaging with low concentrations and minimal incubation.

Prodan-based solvatochromic probes for polarity imaging of organelles

The paper introduces Prodan-based solvatochromic probes for imaging organelle polarity, showing organelle-specific polarity changes under starvation.

Tunable Cytosolic Chloride Indicators for Real-Time Chloride Imaging in Live Cells

This paper develops CytoCl dyes for real-time imaging of cytosolic chloride flux in live cells, revealing rapid changes and enabling first-time single-cell imaging of chloride channel activity.

A Novel Fluorogenic Spin Probe for Real-time Monitoring of Mitochondrial Reactive Oxygen Species (mROS) Generation in an in vitro Stroke Model