Extracellular vesicles in disease

The paper identifies a 5-gene exosomal biomarker panel with high accuracy for predicting liver metastasis in lung cancer patients.

The paper quantifies secreted and extracellular vesicle (EV) urinary proteomes in men with and without prostate cancer, showing their stability and utility in distinguishing malignant from benign lesions.

The paper assesses BEV-enrichment protocols for blood biomarkers in neurodegenerative diseases and identifies CNS-specific proteins for enrichment and biomarker use.

This paper uses magnetic particle imaging to show that iron-labeled extracellular vesicles accumulate in brains of mice with brain metastases but not in mice without metastases.

This study shows hypoxic tumor cells release extracellular vesicles containing ALS2, which activate Rab5 in endothelial cells to promote angiogenesis via β-catenin stabilization.

This study shows that extracellular vesicles from human oral mucosa stem cells promote autophagy in human microglia via lipid raft-dependent mechanisms involving TLR4, HSP70, integrins, and P2X4R.

This paper introduces a novel immunoassay for detecting EGFR and its activity state in plasma CD63-EVs from glioblastoma patients, achieving high sensitivity and specificity for early detection.

This study identifies ciliary intrinsic mechanisms that regulate dynamic extracellular vesicle release from sensory neurons in C. elegans, showing that KLP-6 and TTM-5 are required for sustained release.

This study compares protein cargo differences in mesenchymal stem cell-derived extracellular vesicles isolated by three methods, finding method-specific impacts on proteome composition and biological function.

This paper shows that stress-induced Rab11a-exosomes carrying AREG promote cetuximab resistance in colorectal cancer by activating EGFR signaling in KRAS-wild type cells.

This paper introduces Membrane-Sensing Peptides (MSP) as universal affinity ligands for analyzing Extracellular Vesicles and analogues, demonstrating their ability to detect EV-associated epitopes in clinical samples without prior isolation.

The paper demonstrates that TRAIL-loaded exosomes from induced neural stem cells effectively target and kill brain cancer cells in vitro and in vivo.

This study uses chiral quantum dots to investigate origin-dependent exosome uptake and cargo release mechanisms in different recipient cells.

The paper uses a single-cell transcriptomic atlas to predict cell type-specific extracellular vesicle biology, identifying gene expression patterns and networks associated with EV secretion.

The paper introduces a novel pH-based method for loading therapeutic toxins into extracellular vesicles, preserving their properties and enhancing cargo activity.

The paper identifies APE1-dependent miRNAs secreted via exosomes, showing their prognostic significance in cancer and their regulation by APE1 and hnRNPA2B1.

The paper uses cryo-TEM and a segmentation model to analyze EV architecture, finding consistent structural heterogeneity across different sources and purification methods.

The paper identifies miRNAs selectively loaded into extracellular vesicles from healthy human astrocytes and links them to neurodevelopmental disorders.

The paper shows that breast cancer cell-derived small extracellular vesicles (EVs) become more adhesive and metastatic when produced in stiff matrices, promoting cancer spread through enhanced chemotaxis and fibroblast reprogramming.

This study identifies and characterizes two types of extracellular vesicles from Cryptosporidium parvum sporozoites, revealing their unique protein compositions and potential roles in antigen presentation.

This study shows that altering the microenvironment of mesenchymal stromal cells changes exosome RNA content and improves ligament healing in rats.

This study isolates extracellular vesicles from human milk and neonatal digestive fluid and shows they are taken up by intestinal epithelial cells.

The paper identifies a 'torn bag mechanism' for small extracellular vesicle release through membrane rupture of amphisomes, showing that both ILVs and small EVs originate from different pathways.

This study shows that high-glucose-treated macrophage-derived extracellular vesicles polarize recipient macrophages into M2 and alter skeletal muscle homeostasis, inducing insulin resistance or hyper-phosphorylation depending on glucose concentration.

This study shows that oncogenic β-catenin reduces exosome release in HCC, leading to immune escape by decreasing immune cell infiltration.

This study compares EV extraction methods and preservation agents, finding method-specific differences in yield, purity, and protein profiles.

The paper develops a protocol to subclassify large extracellular vesicles in oral fluid based on physicochemical properties using sedimentation patterns and clustering analysis.

This study uses lipidomics to analyze plasma extracellular vesicles from AUD patients and healthy individuals, revealing sex-based differences in lipid profiles and their potential links to disease mechanisms.

This study isolates and characterizes extracellular vesicles from Pneumocystis-infected rats, showing they impair fungal viability but are not required for macrophage function.