Extracellular vesicles in disease

A Meta-Analysis of 515 Human Proteomes Defines the Core Composition and Contaminants of Plasma Extracellular Vesicles isolates

This study defines the core proteome and contaminants of plasma extracellular vesicles through a meta-analysis of 515 human proteomes, revealing distinct biological sources and functional modules.

Plasmid-plasmid interactions reshape extracellular vesicle cargo and gene transfer potential

This study shows that plasmid-plasmid interactions alter EV cargo composition and gene transfer potential in microbial communities.

Large oncosomes reprogram bone marrow mesenchymal stem cells to establish a pre-metastatic niche

This study shows that large oncosomes reprogram bone marrow mesenchymal stem cells to create a pre-metastatic niche by inducing an interferon-driven inflammatory response.

Multi-omic profiling defines subtype-specific extracellular vesicle signatures in early human pregnancy

The paper compares small and large extracellular vesicles from healthy pregnancies to identify subtype-specific cargo differences and establish a reference for normal EV biology.

Systemically delivered Bacteroides thetaiotaomicron-derived bacterial extracellular vesicles inhibit primary and metastatic melanoma growth

This study shows that Bacteroides thetaiotaomicron-derived extracellular vesicles inhibit melanoma growth via immune activation rather than direct cytotoxicity.

Tuberculous meningitis alters the proteomic landscape of brain-derived extracellular vesicles

This study identifies proteomic changes in brain-derived extracellular vesicles during tuberculous meningitis, revealing shifts toward inflammation and neuronal injury.

Temporal Dynamics of Urinary Extracellular Vesicle Excretion and Cargo in Healthy Subjects over 24 Hours

This study examines the 24-hour excretion patterns of urinary extracellular vesicles (uEVs) and their cargo in healthy subjects, revealing temporal variations and associations with urine parameters.

Complementation of a human disease phenotype in vitro by intercellular mRNA transfer

This study shows that intercellular mRNA transfer via tunneling nanotubes can complement genetic mutations in vitro, as demonstrated by peroxisome biogenesis in Zellweger Syndrome models.

Bioengineered extracellular vesicles mitigate neuroinflammation by neutralizing pneumolysin and delaying disease onset in experimental pneumococcal meningitis

This study develops bioengineered extracellular vesicles that neutralize pneumolysin and reduce inflammation in pneumococcal meningitis, improving survival in a mouse model.

GW4869 depletes macrophages and increases number of extracellular vesicles in murine peritoneal cavity fluid

This study shows that GW4869 reduces macrophages and increases extracellular vesicles in the peritoneal cavity of mice.

Cell-type Specific Extracellular Vesicles in Mouse Brain: Proteomic Signatures Highlight Astrocytic GlialCAM Network and GPCR Enrichment

The paper performs proteomic analysis of brain cell type-specific extracellular vesicles in mice, identifying distinct molecular signatures and highlighting the GlialCAM/MLC1 network in astrocytic EVs.

An integrated cardiac microtissue proteome map extends therapeutic remodelling by nanovesicles

The paper develops a human cardiac microtissue model to study ischemia-reperfusion injury and shows that nanovesicles improve cardiomyocyte survival and function through proteomic changes.

Altered MicroRNA Signatures in Circulating Extracellular Vesicles Reflect Aortic Dilation in Takayasu Arteritis

This study identifies miR-223-3p in extracellular vesicles as a biomarker for aortic dilation in Takayasu arteritis, outperforming traditional inflammatory markers.

Stress-induced switch in small extracellular vesicle secretion: from constitutive 'torn bag mechanism' to exocytosis

The paper identifies two sEV secretion mechanisms, showing that stress activates exocytosis of multivesicular endosomes while steady-state conditions use the 'torn bag mechanism'.

CRISPR activation screen uncovers MARCKSL1 as a gauge for extracellular vesicle secretion.

The paper identifies MARCKSL1 as a regulator of extracellular vesicle secretion pathways through a CRISPR activation screen and functional studies.

A combinatorial EVs-miRNA signature mediates the anti-tumoral activity of NFAT3-regulated extracellular vesicles in aggressive cancers.

The paper identifies a combinatorial miRNA signature in EVs regulated by NFAT3 that suppresses tumor aggressiveness in TNBC and pancreatic cancer models.

Mesenchymal stem cell-extracellular vesicles deliver microRNAs that prevent nerve growth factor-induced sensory neuron sensitization

This study shows that MSC-EVs prevent NGF-induced sensory neuron sensitization through miRNA-mediated transcriptional regulation.

Super homotypic targeting by exosome surface engineering

This paper enhances homotypic targeting by engineering exosome surfaces with lanthanides, significantly improving cell-exosome interactions and enabling new applications in diagnostics and therapy.

Plasma exosomal HERV-K transcripts are increased in amyotrophic lateral sclerosis

The paper quantifies exosomal HERV-K transcripts in ALS patients and controls, finding elevated pol expression that could serve as a biomarker for treatment monitoring.

Music-Inspired Acoustic-Piezoelectric Stimulation Accelerates Extracellular Vesicle Production and Programs Therapeutic Function

This study uses music-inspired acoustic-piezoelectric stimulation to enhance macrophage extracellular vesicle production and control their therapeutic function by tuning polarization states.

Functional profiling of extracellular vesicles from boar reproductive fluids

This study isolates and characterizes extracellular vesicles from boar reproductive fluids and investigates their interaction with sperm and functional roles.

Isolation and preliminary characterization of extracellular vesicles from bottlenose dolphin (Tursiops truncatus) and long-finned pilot whale (Globicephala melas) blow

This study isolates and characterizes extracellular vesicles from bottlenose dolphin and long-finned pilot whale blow samples, showing their presence and potential as biomarkers for cetacean health.

Oral delivery of mesenchymal stem cell-derived extracellular vesicles to treat intestinal inflammation

This study evaluates oral delivery of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) for treating intestinal inflammation, showing improved stability and therapeutic efficacy with a novel coating formulation.

A nucleic acid labeling chemistry reveals surface DNA on exosomes

The paper introduces RUNA, a reversible labeling chemistry to distinguish surface DNA from intracellular DNA on exosomes, revealing its role in immune cell interaction.

Large extracellular vesicles derived from red blood cells in coronary artery disease patients with anemia promote endothelial dysfunction

This study shows that anemia in coronary artery disease patients increases release of red blood cell-derived extracellular vesicles (REVs) that promote endothelial dysfunction by enhancing nitric oxide consumption and oxidative stress.

Proteomic analysis of extracellular vesicles released from endothelial cells in vitro reveals increased levels of E-selectin and dual specificity phosphatase 7 as a potential marker of TNFα-mediated apoptosis

This study identifies E-selectin and dual specificity phosphatase 7 as differentially expressed proteins in TNFα-stimulated endothelial cell extracellular vesicles, suggesting their potential as biomarkers for endothelial apoptosis in cardiovascular disease.

Ceramide-rich extracellular vesicles as pathogenic biomarkers in traumatic brain injury

The paper identifies ceramide-rich extracellular vesicles as biomarkers of traumatic brain injury, showing their role in inflammation and neuronal mitochondrial dysfunction.

Increased mannosylation of extracellular vesicles in Long COVID plasma provides a potential therapeutic target for Galanthus nivalis agglutinin (GNA) affinity resin

The paper identifies increased mannosylation of extracellular vesicles in Long COVID plasma and shows GNA affinity resin can remove them, potentially rebalancing immune and tissue-repair networks.

Generation of Cellular Biofactories for Scalable Production of Surface-Engineered Extracellular Vesicles via CRISPR Genome Editing

This study develops CRISPR-Cas9 engineered HEK293T cells for stable production of surface-engineered extracellular vesicles, showing improved consistency and scalability compared to transient transfection.

Integrated Multi-Omics Enabled by Sequential Extraction for Comprehensive Molecular Profiling of Small Extracellular Vesicles

This paper presents a multi-omics platform for simultaneous lipid, metabolite, and protein analysis of sEVs using sequential extraction and mass spectrometry, achieving deep and reproducible characterization with 10 million sEVs.